I. TOPICS TO DISCUSS I. Drug classifications
Classifications of:
- general anesthetics;
- hypnotics;
- antiepileptic drugs (based on therapeutic use);
- antiepileptic drugs (based on mechanisms of action);
- antiparkinsonian drugs;
- analgesics (central and peripheral);
- opioid analgesics;
- centrally acting nonopioid analgesics;
- antipsychotic drugs;
- antidepressants;
- anxiolytics;
- CNS stimulants.
II. Mechanisms of action
1. Mechanism of CNS depressant action of ben-zodiazepines and barbiturates (based on the corresponding diagram).
2. Mechanism of analgesic action of morphine, buprenorphine, butorphanol.
3. Mechanism of analgesic action of imipramine and amitriptyline.
4. Mechanism of analgesic action of acetylsali-cylic acid (based on the diagram of arachidonic acid metabolism).
6. Mechanism and sites of action of levodopa, selegiline, amantadine, bromocriptine, entacapone, trihexyphenidyl in Parkinson's disease (based on the diagrams of dopaminergic synapse and nigros-triatal pathway).
7. Mechanism of antipsychotic action of chlor-promazine.
8. Mechanism of action of tricyclic antidepres-sants, fluoxetine and MAO inhibitors (based on the diagram of monoaminergic synapses).
9. Mechanism of anxiolytic action of buspirone, duloxetine, trazodone.
10. Mechanism of CNS stimulant action of amphetamines (based on the diagram of monoaminer-gic synapses).
11. Mechanism of pharmacological effects of caffeine.
III. Pharmacological effects
1. Pharmacological effects of general anesthetics: sevoflurane, enflurane, nitrous oxide, thiopental, ketamine.
2. Pharmacology of ethanol.
3. Pharmacological effects of morphine.
4. Comparison of agonists, agonists-antagonists and partial agonists of opioid receptors.