17. TYPICAL FORMS OF PATHOLOGY OF HEMOSTASIS

I. Which of the following substances can split the fibrin molecule in the process of fibrinolysis?

1. Plasminogen.

2. Plasmin.

3. Antiplasmin.

4. Heparin-like molecule.

5. Antithrombin III.

6. Protein C.

II. Which of the following coagulation factors are reduced or absent in hemophilia A?

1. Factor I.

2. Factor III.

3. Factor VIII.

4. Factor X.

5. Factor XII.

III. Thrombocytopenia may be observed in the following conditions:

1. Acute leukemia.

2. Splenomegaly.

3. Folate or the vitamin B₁₂ deficiency.

4. Glanzmann's disease.

5. Scurvy.

6. Congestive heart failure.

7. Transfusion reactions.

IV. The vitamin K deficiency results in the insufficiency of the following coagulation factors:

1. Prothrombin (II).

2. Factor V.

3. Factor VII.

4. Factor IX.

5. Factor XII.

6. Factor X.

V. Platelets adhesion to collagen is mediated by the following glycoprotein receptors:

1. Ia/IIb.

2. IIb/IIIa.

3. Ia/IX.

VI. Which of the following factors induce platelet aggregation?

1. Thromboxane A₂.

2. NO.

3. ADP.

4. ATP.

5. Prostacycline I₂.

6. Epinephrine.

VII. Which of the following hereditary disorders are associated with the thrombotic syndrome?

1. Mutations in factor V.

2. Inherent lack of the antithrombin III.

3. Inherent lack of the protein C.

4. Inherent lack of the protein S.

5. Increased production of t-PA (tissue plasminogen activator).

VIII. Choose the causes of nonthrombocytopenic purpuras:

1. Meningococcemia.

2. Severe measles.

3. Scurvey.

4. Leukemia.

5. Cushing's syndrome.

6. Posttransfusion reaction.

7. Hypersplenism.

IX. Excessive bleeding from wounds, menorrhagia and prolong bleeding time in the presence of a normal platelet count are typical to the following disorders:

1. Hemophilia A.

2. Hemophilia B.