Поиск
Закладки
Озвучить текст Озвучить книгу
Изменить режим чтения
Изменить размер шрифта
Оглавление
Для озвучивания и цитирования книги перейдите в режим постраничного просмотра.
Неалкогольная жировая болезнь печени

Список литературы

  1. Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797–1835. https://doi.org/10.1097/HEP.0000000000000323
  2. Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023;78(6):1966–1986. https://doi.org/10.1097/HEP.0000000000000520.
  3. ICD-11. International Classification of Diseases 11th Revision. Available at: https://icd.who.int.
  4. Singh S, Allen AM, Wang Z, Prokop LJ, Murad MH, Loomba R. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. 2015;13(4):643–654.e1–9. https://doi.org/10.1016/j.cgh.2014.04.014.
  5. Райхельсон К.Л., Маевская М.В., Жаркова М.С., Гречишникова В.Р., Оковитый С.В., Деева Т.А., Марченко Н.В., Прашнова М.К., Ивашкин В.Т. Жировая болезнь печени: новая номенклатура и ее адаптация в Российской Федерации. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2024;34(2):35–44. https://doi.org/10.22416/1382- 4376-2024-34-2-35-44
  6. Day CP, James OF. Steatohepatitis: a tale of two “hits”? Gastroenterology. 1998;114(4):842–845. https://doi.org/10.1016/s0016-5085(98)70599-2.
  7. Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol. 2015;62(Suppl. 1):S47–64. https://doi.org/10.1016/j.jhep.2014.12.012.
  8. Xian YX, Weng JP, Xu F. MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy. Chin Med J (Engl). 2020;134(1):8–19. https://doi.org/10.1097/CM9.0000000000001263.
  9. Parthasarathy G, Revelo X, Malhi H. Pathogenesis of Nonalcoholic Steatohepatitis: An Overview. Hepatol Commun. 2020;4(4):478–492. https://doi.org/10.1002/hep4.1479.
  10. Haas JT, Francque S, Staels B. Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease. Annu Rev Physiol. 2016;78:181–205. https://doi.org/10.1146/annurev-physiol-021115-105331.
  11. Basaranoglu M, Basaranoglu G, Bugianesi E. Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destruction. Hepatobiliary Surg Nutr. 2015;4(2):109–116. https://doi.org/10.3978/j.issn.2304-3881.2014.11.05.
  12. Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C et al. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018;68(5):1063–1075. https://doi.org/10.1016/j.jhep.2018.01.019.
  13. Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology. 2014;59(2):713–723. https://doi.org/10.1002/hep.26672.
  14. Ipsen DH, Lykkesfeldt J, Tveden-Nyborg P. Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. Cell Mol Life Sci. 2018;75(18):3313–3327. https://doi.org/10.1007/s00018-018-2860-6.
  15. Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology. 2014;146(3):726–735. https://doi.org/10.1053/j.gastro.2013.11.049.
  16. Ter Horst KW, Serlie MJ. Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease. Nutrients. 2017;9(9):981. https://doi.org/10.3390/nu9090981.
  17. Shen J, Sakaida I, Uchida K, Terai S, Okita K. Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells. Life Sci. 2005;77(13):1502–1515. https://doi.org/10.1016/j.lfs.2005.04.004.
  18. Subichin M, Clanton J, Makuszewski M, Bohon A, Zografakis JG, Dan A. Liver disease in the morbidly obese: a review of 1000 consecutive patients undergoing weight loss surgery. Surg Obes Relat Dis. 2015;11(1):137–141. https://doi.org/10.1016/j.soard.2014.06.015.
  19. Sasaki A, Nitta H, Otsuka K, Umemura A, Baba S, Obuchi T, Wakabayashi G. Bariatric surgery and non-alcoholic Fatty liver disease: current and potential future treatments. Front Endocrinol (Lausanne). 2014;5:164. https://doi.org/10.3389/fendo.2014.00164.
  20. Stojsavljević S, Gomerčić Palčić M, Virović Jukić L, Smirčić Duvnjak L, Duvnjak M. Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20(48):18070–18091. https://doi.org/10.3748/wjg.v20.i48.18070.
  21. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012;18(3):363–374. https://doi.org/10.1038/nm.2627.
  22. Yan FJ, Wang X, Wang SE, Hong HT, Lu J, Ye Q et al. C-Jun/C7ORF41/NF-κB axis mediates hepatic inflammation and lipid accumulation in NAFLD. Biochem J. 2020;477(3):691–708. https://doi.org/10.1042/BCJ20190799.
  23. Jin S, Li Y, Xia T, Liu Y, Zhang S, Hu H et al. Mechanisms and therapeutic implications of selective autophagy in nonalcoholic fatty liver disease. J Adv Res. 2024:S2090-1232(24)00041-9. https://doi.org/10.1016/j.jare.2024.01.027.
  24. Prerna K, Dubey VK. Beclin1-mediated interplay between autophagy and apoptosis: New understanding. Int J Biol Macromol. 2022;204:258–273. https://doi.org/10.1016/j.ijbiomac.2022.02.005.
  25. Fromenty B, Roden M. Mitochondrial alterations in fatty liver diseases. J Hepatol. 2023;78(2):415–429. https://doi.org/10.1016/j.jhep.2022.09.020.
  26. Ferré P, Foufelle F. SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm Res. 2007;68(2):72–82. https://doi.org/10.1159/000100426.
  27. Miserez AR, Muller PY, Barella L, Barella S, Staehelin HB, Leitersdorf E et al. Sterol-regulatory element-binding protein (SREBP)-2 contributes to polygenic hypercholesterolaemia. Atherosclerosis. 2002;164(1):15–26. https://doi.org/10.1016/s0021-9150(01)00762-6.
  28. Iizuka K, Takao K, Yabe D. ChREBP-Mediated Regulation of Lipid Metabolism: Involvement of the Gut Microbiota, Liver, and Adipose Tissue. Front Endocrinol (Lausanne). 2020;11:587189. https://doi.org/10.3389/fendo.2020.587189.
  29. Ma M, Xie W, Li X. Identification of Autophagy-Related Genes in the Progression from Non-Alcoholic Fatty Liver to Non-Alcoholic Steatohepatitis. Int J Gen Med. 2021;14:3163–3176. https://doi.org/10.2147/IJGM.S317785.
  30. Barrientos-Riosalido A, Real M, Bertran L, Aguilar C, Martínez S, Parada D et al. Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity. Int J Mol Sci. 2023;24(2):1324. https://doi.org/10.3390/ijms24021324.
  31. Syed-Abdul MM. Lipid Metabolism in Metabolic-Associated Steatotic Liver Disease (MASLD). Metabolites. 2023;14(1):12. https://doi.org/10.3390/metabo14010012.
  32. Branković M, Dukić M, Gmizić T, Popadić V, Nikolić N, Sekulić A et al. New Therapeutic Approaches for the Treatment of Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Increased Cardiovascular Risk. Diagnostics (Basel). 2024;14(2):229. https://doi.org/10.3390/diagnostics14020229.
  33. Zhao Y, Zhou Y, Wang D, Huang Z, Xiao X, Zheng Q et al. Mitochondrial Dysfunction in Metabolic Dysfunction Fatty Liver Disease (MAFLD). Int J Mol Sci. 2023;24(24):17514. https://doi.org/10.3390/ijms242417514.
  34. Chen Z, Tian R, She Z, Cai J, Li H. Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. Free Radic Biol Med. 2020;152:116–141. https://doi.org/10.1016/j.freeradbiomed.2020.02.025.
  35. Thomson AW, Knolle PA. Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol. 2010;10(11):753–766. https://doi.org/10.1038/nri2858.
  36. Lotze MT, Zeh HJ, Rubartelli A, Sparvero LJ, Amoscato AA, Washburn NR et al. The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity. Immunol Rev. 2007;220:60–81. https://doi.org/10.1111/j.1600-065X.2007.00579.x.
  37. Szabo G, Csak T. Inflammasomes in liver diseases. J Hepatol. 2012;57(3):642–654. https://doi.org/10.1016/j.jhep.2012.03.035.
  38. Luedde T, Schwabe RF. NF-κB in the liver – linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2011;8(2):108–118. https://doi.org/10.1038/nrgastro.2010.213.
  39. Klein I, Cornejo JC, Polakos NK, John B, Wuensch SA, Topham DJ et al. Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages. Blood. 2007;110(12):4077–4085. https://doi.org/10.1182/blood-2007-02-073841.
  40. Fang YL, Chen H, Wang CL, Liang L. Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”. World J Gastroenterol. 2018;24(27):2974–2983. https://doi.org/10.3748/wjg.v24.i27.2974.
  41. Tomita K, Tamiya G, Ando S, Ohsumi K, Chiyo T, Mizutani A et al. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. Gut. 2006;55(3):415–424. https://doi.org/10.1136/gut.2005.071118.
  42. Kremer M, Hines IN, Milton RJ, Wheeler MD. Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis. Hepatology. 2006;44(1):216–227. https://doi.org/10.1002/hep.21221.
  43. Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H et al. Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome. Sci Immunol. 2017;2(10):eaai7616. https://doi.org/10.1126/sciimmunol.aai7616.
  44. Wang M, Li L, Xu Y, Du J, Ling C. Roles of hepatic stellate cells in NAFLD: From the perspective of inflammation and fibrosis. Front Pharmacol. 2022;13:958428. https://doi.org/10.3389/fphar.2022.958428.
  45. Li Z, Yuan H, Chu H, Yang L. The Crosstalk between Gut Microbiota and Bile Acids Promotes the Development of Non-Alcoholic Fatty Liver Disease. Microorganisms. 2023;11(8):2059. https://doi.org/10.3390/microorganisms11082059.
  46. Clemente MG, Mandato C, Poeta M, Vajro P. Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions. World J Gastroenterol. 2016;22(36):8078–8093. https://doi.org/10.3748/wjg.v22.i36.8078.
  47. Ulluwishewa D, Anderson RC, McNabb WC, Moughan PJ, Wells JM, Roy NC. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 2011;141(5):769–776. https://doi.org/10.3945/jn.110.135657.
  48. Paolella G, Mandato C, Pierri L, Poeta M, Di Stasi M, Vajro P. Gut-liver axis and probiotics: their role in non-alcoholic fatty liver disease. World J Gastroenterol. 2014;20(42):15518–15531. https://doi.org/10.3748/wjg.v20.i42.15518.
  49. Zorn AM, Wells JM. Vertebrate endoderm development and organ formation. Annu Rev Cell Dev Biol. 2009;25:221–251. https://doi.org/10.1146/annurev.cellbio.042308.113344.
  50. Fairfield CJ, Drake TM, Pius R, Bretherick AD, Campbell A, Clark DW et al. Genome-Wide Association Study of NAFLD Using Electronic Health Records. Hepatol Commun. 2022;6(2):297–308. https://doi.org/10.1002/hep4.1805.
  51. Anstee QM, Darlay R, Cockell S, Meroni M, Govaere O, Tiniakos D et al. Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort. J Hepatol. 2020;73(3):505–515. https://doi.org/10.1016/j.jhep.2020.04.003.
  52. Куртанов ХА, Сыдыкова ЛА, Павлова НИ, Филиппова НП, Додохов ВВ, Апсолихова ГА и др. Полиморфизм гена адипонутрина (PNPLAЗ) у коренных жителей Республики Саха (Якутия), страдающих сахарным диабетом 2-го типа. Альманах клинической медицины. 2018;46(3):258–263. https://doi.org/10.18786/2072-0505-2018-46-3-258-263.
  53. Кролевец ТС, Ливзан МА, Ахмедов ВА, Новиков ДГ. Исследование полиморфизма гена PNPLA3 у пациентов с неалкогольной жировой болезнью печени и различной стадией фиброза. Экспериментальная и клиническая гастроэнтерология. 2018;(11):24–32. Режим доступа: https://www.nogr.org/jour/article/view/1088.
  54. Райхельсон КЛ, Ковязина ВП, Сидоренко ДВ, Назаров ВД, Лапин СВ, Эмануэль ВЛ и др. Влияние полиморфизма гена PNPLA3 на течение неалкогольной жировой болезни печени. РМЖ. 2019;(12):85–88. Режим доступа: https://www.rmj.ru/articles/gastroenterologiya/Vliyanie_polimorfizma_gena_PNPLA3_na_techenie_nealkogolynoy_ghirovoy_bolezni_pecheni/.
  55. Дьяконова АТ, Куртанов ХА, Павлова НИ, Соловьева НА, Соловьева ЮА, Филиппова НП, Александрова ТН. Полиморфизм rs58542926 гена TM6SF2 при хронических неинфекционных болезнях печени в якутской популяции. Современные проблемы науки и образования. 2019;(6). https://doi.org/10.17513/spno.29334.
  56. Cusi K, Isaacs S, Barb D, Basu R, Caprio S, Garvey WT et al. American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD). Endocr Pract. 2022;28(5):528–562. https://doi.org/10.1016/j.eprac.2022.03.010.
  57. Lonardo A, Ballestri S, Mantovani A, Nascimbeni F, Lugari S, Targher G. Pathogenesis of hypothyroidism-induced NAFLD: Evidence for a distinct disease entity? Dig Liver Dis. 2019;51(4):462–470. https://doi.org/10.1016/j.dld.2018.12.014.
  58. Ramanathan R, Patwa SA, Ali AH, Ibdah JA. Thyroid Hormone and Mitochondrial Dysfunction: Therapeutic Implications for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Cells. 2023;12(24):2806. https://doi.org/10.3390/cells12242806.
  59. Younossi ZM, Henry L. Understanding the Burden of Nonalcoholic Fatty Liver Disease: Time for Action. Diabetes Spectr. 2024;37(1):9–19. https://doi.org/10.2337/dsi23-0010.
  60. Jichitu A, Bungau S, Stanescu AMA, Vesa CM, Toma MM, Bustea C et al. Non-Alcoholic Fatty Liver Disease and Cardiovascular Comorbidities: Pathophysiological Links, Diagnosis, and Therapeutic Management. Diagnostics (Basel). 2021;11(4):689. https://doi.org/10.3390/diagnostics11040689.
  61. Драпкина ОМ, Ивашкин ВТ. Эпидемиологические особенности неалкогольной жировой болезни печени в России (результаты открытого многоцентрового проспективного исследования-наблюдения DIREG L 01903). Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2014;24(4):32–38. Режим доступа: https://www.elibrary.ru/tezcyf.
  62. Ивашкин ВТ, Драпкина ОМ, Маев ИВ, Трухманов АС, Блинов ДВ, Пальгова ЛК и др. Распространенность неалкогольной жировой болезни печени у пациентов амбулаторно-поликлинической практики в Российской Федерации: результаты исследования DIREG 2. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2015;25(6):31–41. Режим доступа: https://www.gastro-j.ru/jour/article/view/1036.
  63. Евстифеева СЕ, Шальнова СА, Куценко ВА, Яровая ЕБ, Баланова ЮА, Имаева АЭ и др. Распространенность неалкогольной жировой болезни печени среди населения трудоспособного возраста: ассоциации с социально-демографическими показателями и поведенческими факторами риска (данные ЭССЕ-РФ-2). Кардиоваскулярная терапия и профилактика. 2022;21(9):3356. https://doi.org/10.15829/1728-8800-2022-3356.
  64. Маев ИВ, Андреев ДН, Кучерявый ЮА. Распространенность неалкогольной жировой болезни печени в России: метаанализ. Consilium Medicum. 2023;25(5):313–319. https://doi.org/10.26442/20751753.2023.5.202155.
  65. Povsic M, Wong OY, Perry R, Bottomley J. A Structured Literature Review of the Epidemiology and Disease Burden of Non-Alcoholic Steatohepatitis (NASH). Adv Ther. 2019;36(7):1574–1594. https://doi.org/10.1007/s12325-019-00960-3.
  66. Harrison SA, Gawrieh S, Roberts K, Lisanti CJ, Schwope RB, Cebe KM et al. Prospective evaluation of the prevalence of non-alcoholic fatty liver disease and steatohepatitis in a large middle-aged US cohort. J Hepatol. 2021;75(2):284–291. https://doi.org/10.1016/j.jhep.2021.02.034.
  67. Estes C, Anstee QM, Arias-Loste MT, Bantel H, Bellentani S, Caballeria J et al. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030. J Hepatol. 2018;69(4):896–904. https://doi.org/10.1016/j.jhep.2018.05.036.
  68. Huang DQ, Terrault NA, Tacke F, Gluud LL, Arrese M, Bugianesi E, Loomba R. Global epidemiology of cirrhosis – aetiology, trends and predictions. Nat Rev Gastroenterol Hepatol. 2023;20(6):388–398. https://doi.org/10.1038/s41575-023-00759-2.
  69. Huang DQ, El-Serag HB, Loomba R. Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2021;18(4):223–238. https://doi.org/10.1038/s41575-020-00381-6.
  70. Ивашкин ВТ, Маевская МВ, Жаркова МС, Жигалова СБ, Киценко ЕА, Манукьян ГВ, Тихонов ИН. Цирроз и фиброз печени: клинические рекомендации. М.; 2021. 99 с. Режим доступа: https://cr.minzdrav.gov.ru/recomend/715_1.
  71. Muthiah MD, Cheng Han N, Sanyal AJ. A clinical overview of non-alcoholic fatty liver disease: A guide to diagnosis, the clinical features, and complications – What the non-specialist needs to know. Diabetes Obes Metab. 2022;24(Suppl. 2):3–14. https://doi.org/10.1111/dom.14521.
  72. Cook N, Geier A, Schmid A, Hirschfield G, Kautz A, Schattenberg JM, Balp MM. The Patient Perspectives on Future Therapeutic Options in NASH and Patient Needs. Front Med (Lausanne). 2019;6:61. https://doi.org/10.3389/fmed.2019.00061.
  73. Liebe R, Esposito I, Bock HH, Vom Dahl S, Stindt J, Baumann U et al. Diagnosis and management of secondary causes of steatohepatitis. J Hepatol. 2021;74(6):1455–1471. https://doi.org/10.1016/j.jhep.2021.01.045.
  74. Ивашкин ВТ. Пропедевтика внутренних болезней: учебник. 2-е изд. М.: ГЭОТАР-Медиа; 2023. 936 с.
  75. Ивашкин ВТ, Маевская МВ, Жаркова МС, Котовская ЮВ, Ткачева ОН, Трошина ЕА и др. Клинические рекомендации Российского общества по изучению печени, Российской гастроэнтерологической ассоциации, Российской ассоциации эндокринологов, Российской ассоциации геронтологов и гериатров и Национального общества профилактической кардиологии по диагностике и лечению неалкогольной жировой болезни печени. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2022;32(4):104–140. https://doi.org/10.22416/1382-4376-2022-32-4-104-140.
  76. Obika M, Noguchi H. Diagnosis and evaluation of nonalcoholic fatty liver disease. Exp Diabetes Res. 2012:145754. https://doi.org/10.1155/2012/145754.
  77. Павлов ЧС, Глушенков ДВ, Коновалова ОН, Ивашкин ВТ. Сфера клинического применения неинвазивных методов оценки фиброза печени: результаты собственных исследований в многопрофильном стационаре. Клиническая медицина. 2009;87(11):40–45. Режим доступа: https://www.elibrary.ru/lajkvx.
  78. Sorbi D, Boynton J, Lindor KD. The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease. Am J Gastroenterol. 1999;94(4):1018–1022. https://doi.org/10.1111/j.1572-0241.1999.01006.x.
  79. Дедов ИИ, Шестакова МВ, Майоров АЮ, Шамхалова МШ, Сухарева ОЮ, Галстян ГР и др. Сахарный диабет 2-го типа у взрослых: клинические рекомендации. М.; 2022. 251 с. Режим доступа: https://cr.minzdrav.gov.ru/recomend/290_2.
  80. Fujii H, Kawada N. The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease. Int J Mol Sci. 2020;21(11):3863. https://doi.org/10.3390/ijms21113863.
  81. Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010;363(14):1341–1350. https://doi.org/10.1056/NEJMra0912063.
  82. Кутишенко НП, Марцевич СЮ, Лерман ОВ, Балашов ИС, Невзорова ВА, Резник ИИ и др. Повышение эффективности гиполипидемической терапии у пациентов высокого сердечно-сосудистого риска с сочетанной патологией печени (результаты дополнительного анализа исследования РАКУРС). Рациональная фармакотерапия в кардиологии. 2015;11(3):297–303. https://doi.org/10.20996/1819-6446-2015-11-3-297-303.
  83. Ежов МВ, Кухарчук ВВ, Сергиенко ИВ, Алиева АС, Анциферов МБ, Аншелес АА и др. Нарушения липидного обмена: клинические рекомендации. М.; 2023. 103 с. https://cr.minzdrav.gov.ru/recomend/752_1.
  84. Spinosa M, Stine JG. Nonalcoholic Fatty Liver Disease-Evidence for a Thrombophilic State? Curr Pharm Des. 2020;26(10):1036–1044. https://doi.org/10.2174/1381612826666200131101553.
  85. Verrijken A, Francque S, Mertens I, Prawitt J, Caron S, Hubens G et al. Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Hepatology. 2014;59(1):121–129. https://doi.org/10.1002/hep.26510.
  86. Balta G, Altay C, Gurgey A. PAI-1 gene 4G/5G genotype: A risk factor for thrombosis in vessels of internal organs. Am J Hematol. 2002;71(2):89–93. https://doi.org/10.1002/ajh.10192.
  87. Northup PG, Argo CK, Shah N, Caldwell SH. Hypercoagulation and thrombophilia in nonalcoholic fatty liver disease: mechanisms, human evidence, therapeutic implications, and preventive implications. Semin Liver Dis. 2012;32(1):39–48. https://doi.org/10.1055/s-0032-1306425.
  88. Skurk T, Hauner H. Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1. Int J Obes Relat Metab Disord. 2004;28(11):1357–1364. https://doi.org/10.1038/sj.ijo.0802778.
  89. Kotronen A, Joutsi-Korhonen L, Sevastianova K, Bergholm R, Hakkarainen A, Pietiläinen KH et al. Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease. Liver Int. 2011;31(2):176–183. https://doi.org/10.1111/j.1478-3231.2010.02375.x.
  90. Ciardullo S, Ballabeni C, Trevisan R, Perseghin G. Liver Stiffness, Albuminuria and Chronic Kidney Disease in Patients with NAFLD: A Systematic Review and Meta-Analysis. Biomolecules. 2022;12(1):105. https://doi.org/10.3390/biom12010105.
  91. Sun DQ, Jin Y, Wang TY, Zheng KI, Rios RS, Zhang HY et al. MAFLD and risk of CKD. Metabolism. 2021;115:154433. https://doi.org/10.1016/j.metabol.2020.154433.
  92. Бобкова ИН, Ватазин АВ, Ветчинникова ОН, Волгина ГВ, Голубев РВ, Горелова ЕА и др. Хроническая болезнь почек (ХБП): клинические рекомендации. М.; 2021. 233 с. Режим доступа: https://cr.minzdrav.gov.ru/recomend/469_2.
  93. Маевская МВ, Котовская ЮВ, Ивашкин ВТ, Ткачева ОН, Трошина ЕА, Шестакова МВ и др. Национальный Консенсус для врачей по ведению взрослых пациентов с неалкогольной жировой болезнью печени и ее основными коморбидными состояниями. Терапевтический архив. 2022;94(2):216–253. https://doi.org/10.26442/00403660.2022.02.201363.
  94. Darmawan G, Hamijoyo L, Hasan I. Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis. Acta Med Indones. 2017;49(2):136–147. Available at: https://www.actamedindones.org/index.php/ijim/article/view/381/pdf.
  95. Lombardi R, Pisano G, Fargion S. Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD. Int J Mol Sci. 2016;17(4):548. https://doi.org/10.3390/ijms17040548.
  96. Аверкина НА, Багаева МЭ, Батышева ТТ, Быкова ОВ, Вашакмадзе НД, Волынец ГВ и др. Нарушения обмена меди (болезнь Вильсона): клинические рекомендации. М.; 2021. 66 с. Режим досутпа: https://cr.minzdrav.gov.ru/recomend/376_2.
  97. Ивашкин ВТ, Ющук НД, Богомолов ПО, Волчкова ЕВ, Дмитриев АС, Жаркова МС и др. Хронический вирусный гепатит С: клинические рекомендации. М.; 2021. 71 с. Режим досутпа: https://cr.minzdrav.gov.ru/recomend/516_2.
  98. Ивашкин ВТ, Маевская МВ, Жаркова МС, Тихонов ИН, Федосьина ЕА, Павлов ЧС. Алгоритмы диагностики и лечения в гепатологии: справочные материалы. М.: МЕДпресс-информ; 2016. 176 с.
  99. Petzold G. Role of Ultrasound Methods for the Assessment of NAFLD. J Clin Med. 2022;11(15):4581. https://doi.org/10.3390/jcm11154581.
  100. Ferraioli G, Soares Monteiro LB. Ultrasound-based techniques for the diagnosis of liver steatosis. World J Gastroenterol. 2019;25(40):6053–6062. https://doi.org/10.3748/wjg.v25.i40.6053.
  101. Hernaez R, Lazo M, Bonekamp S, Kamel I, Brancati FL, Guallar E, Clark JM. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology. 2011 Sep 2;54(3):1082-1090. doi: 10.1002/hep.24452.
  102. European Association for the Study of the Liver. EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update. J Hepatol. 2021;75(3):659–689. https://doi.org/10.1016/j.jhep.2021.05.025.
  103. Petroff D, Blank V, Newsome PN, Shalimar, Voican CS, Thiele M et al. Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis. Lancet Gastroenterol Hepatol. 2021;6(3):185–198. https://doi.org/10.1016/S2468-1253(20)30357-5.
  104. Pu K, Wang Y, Bai S, Wei H, Zhou Y, Fan J, Qiao L. Diagnostic accuracy of controlled attenuation parameter (CAP) as a non-invasive test for steatosis in suspected non-alcoholic fatty liver disease: a systematic review and meta-analysis. BMC Gastroenterol. 2019;19(1):51. https://doi.org/10.1186/s12876-019-0961-9.
  105. Gu J, Liu S, Du S, Zhang Q, Xiao J, Dong Q, Xin Y. Diagnostic value of MRI-PDFF for hepatic steatosis in patients with non-alcoholic fatty liver disease: a meta-analysis. Eur Radiol. 2019;29(7):3564–3573. https://doi.org/10.1007/s00330-019-06072-4.
  106. Verhaegh P, Bavalia R, Winkens B, Masclee A, Jonkers D, Koek G. Noninvasive Tests Do Not Accurately Differentiate Nonalcoholic Steatohepatitis From Simple Steatosis: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2018;16(6):837–861. https://doi.org/10.1016/j.cgh.2017.08.024.
  107. Kleiner DE, Brunt EM. Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical research. Semin Liver Dis. 2012;32(1):3–13. https://doi.org/10.1055/s-0032-1306421.
  108. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313–1321. https://doi.org/10.1002/hep.20701.
  109. Bedossa P. Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease. Hepatology. 2014;60(2):565–575. https://doi.org/10.1002/hep.27173.
  110. Bedossa P. Current histological classification of NAFLD: strength and limitations. Hepatol Int. 2013;7(Suppl. 2):765–770. https://doi.org/10.1007/s12072-013-9446-z
  111. Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 2003;98(11):2485–2490. https://doi.org/10.1111/j.1572-0241.2003.08699.x.
  112. Xiao G, Zhu S, Xiao X, Yan L, Yang J, Wu G. Comparison of laboratory tests, ultrasound, or magnetic resonance elastography to detect fibrosis in patients with nonalcoholic fatty liver disease: A meta-analysis. Hepatology. 2017;66(5):1486–1501. https://doi.org/10.1002/hep.29302.
  113. McPherson S, Hardy T, Dufour JF, Petta S, Romero-Gomez M, Allison M et al. Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis. Am J Gastroenterol. 2017;112(5):740–751. https://doi.org/10.1038/ajg.2016.453.
  114. Bril F, McPhaul MJ, Caulfield MP, Clark VC, Soldevilla-Pico C, Firpi-Morell RJ et al. Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes. Diabetes Care. 2020;43(2):290–297. https://doi.org/10.2337/dc19-1071.
  115. Papatheodoridi M, Hiriart JB, Lupsor-Platon M, Bronte F, Boursier J, Elshaarawy O et al. Refining the Baveno VI elastography criteria for the definition of compensated advanced chronic liver disease. J Hepatol. 2021;74(5):1109–1116. https://doi.org/10.1016/j.jhep.2020.11.050.
  116. De Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C. Baveno VII – Renewing consensus in portal hypertension. J Hepatol. 2022;76(4):959–974. https://doi.org/10.1016/j.jhep.2021.12.022.
  117. WHO guidelines on physical activity and sedentary behaviour. Available at: https://iris.who.int/bitstream/handle/10665/336656/9789240015128-eng.pdf.
  118. Keating SE, Hackett DA, George J, Johnson NA. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol. 2012;57(1):157–166. https://doi.org/10.1016/j.jhep.2012.02.023.
  119. Дедов ИИ, Мокрышева НГ, Мельниченко ГА, Трошина ЕА, Мазурина НВ, Ершова ЕВ и др. Ожирение: клинические рекомендации. М.; 2020. Режим доступа: https://cr.minzdrav.gov.ru/recomend/28_2.
  120. Hashida R, Kawaguchi T, Bekki M, Omoto M, Matsuse H, Nago T et al. Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review. J Hepatol. 2017;66(1):142–152. https://doi.org/10.1016/j.jhep.2016.08.023.
  121. Katsagoni CN, Georgoulis M, Papatheodoridis GV, Panagiotakos DB, Kontogianni MD. Effects of lifestyle interventions on clinical characteristics of patients with non-alcoholic fatty liver disease: A meta-analysis. Metabolism. 2017;68:119–132. https://doi.org/10.1016/j.metabol.2016.12.006.
  122. Golabi P, Locklear CT, Austin P, Afdhal S, Byrns M, Gerber L, Younossi ZM. Effectiveness of exercise in hepatic fat mobilization in non-alcoholic fatty liver disease: Systematic review. World J Gastroenterol. 2016;22(27):6318–6327. https://doi.org/10.3748/wjg.v22.i27.6318.
  123. Smart NA, King N, McFarlane JR, Graham PL, Dieberg G. Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis. Br J Sports Med. 2018;52(13):834–843. https://doi.org/10.1136/bjsports-2016-096197.
  124. Cheng S, Ge J, Zhao C, Le S, Yang Y, Ke D et al. Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial. Sci Rep. 2017;7(1):15952. https://doi.org/10.1038/s41598-017-16159-x.
  125. Hallsworth K, Thoma C, Hollingsworth KG, Cassidy S, Anstee QM, Day CP, Trenell MI. Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial. Clin Sci (Lond). 2015;129(12):1097–1105. https://doi.org/10.1042/CS20150308.
  126. Rector RS, Thyfault JP, Morris RT, Laye MJ, Borengasser SJ, Booth FW, Ibdah JA. Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol. 2008;294(3):G619–626. https://doi.org/10.1152/ajpgi.00428.2007.
  127. Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797–1835. https://doi.org/10.1097/HEP.0000000000000323.
  128. Zelber-Sagi S, Salomone F, Mlynarsky L. The Mediterranean dietary pattern as the diet of choice for non-alcoholic fatty liver disease: Evidence and plausible mechanisms. Liver Int. 2017;37(7):936–949. https://doi.org/10.1111/liv.13435.
  129. Haigh L, Kirk C, El Gendy K, Gallacher J, Errington L, Mathers JC, Anstee QM. The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis. Clin Nutr. 2022;41(9):1913–1931. https://doi.org/10.1016/j.clnu.2022.06.037.
  130. Younossi ZM, Corey KE, Lim JK. AGA Clinical Practice Update on Lifestyle Modification Using Diet and Exercise to Achieve Weight Loss in the Management of Nonalcoholic Fatty Liver Disease: Expert Review. Gastroenterology. 2021;160(3):912–918. https://doi.org/10.1053/j.gastro.2020.11.051.
  131. Panchal SK, Poudyal H, Brown L. Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. J Nutr. 2012;142(6):1026–1032. https://doi.org/10.3945/jn.111.157263.
  132. Aller R, Izaola O, de la Fuente B, De Luis Román DA. Mediterranean diet is associated with liver histology in patients with non alcoholic fatty liver disease. Nutr Hosp. 2015;32(6):2518–2524. https://doi.org/10.3305/nh.2015.32.6.10074.
  133. Abenavoli L, Greco M, Nazionale I, Peta V, Milic N, Accattato F et al. Effects of Mediterranean diet supplemented with silybin-vitamin E-phospholipid complex in overweight patients with non-alcoholic fatty liver disease. Expert Rev Gastroenterol Hepatol. 2015;9(4):519–527. https://doi.org/10.1586/17474124.2015.1004312.
  134. Ryan MC, Itsiopoulos C, Thodis T, Ward G, Trost N, Hofferberth S et al. The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease. J Hepatol. 2013;59(1):138–143. https://doi.org/10.1016/j.jhep.2013.02.012.
  135. Trovato FM, Martines GF, Brischetto D, Trovato G, Catalano D. Neglected features of lifestyle: Their relevance in non-alcoholic fatty liver disease. World J Hepatol. 2016;8(33):1459–1465. https://doi.org/10.4254/wjh.v8.i33.1459.
  136. Lee D, Chiavaroli L, Ayoub-Charette S, Khan TA, Zurbau A, Au-Yeung F et al. Important Food Sources of Fructose-Containing Sugars and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Controlled Trials. Nutrients. 2022;14(14):2846. https://doi.org/10.3390/nu14142846.
  137. Liu W, Zhai D, Zhang T, Mudoti NG, Chang Q, Liu Y et al. Meta-analysis of the association between major foods with added fructose and non-alcoholic fatty liver disease. Food Funct. 2023;14(12):5551–5561. https://doi.org/10.1039/d3fo00882g.
  138. Wong VW, Wong GL, Chan RS, Shu SS, Cheung BH, Li LS et al. Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease. J Hepatol. 2018;69(6):1349–1356. https://doi.org/10.1016/j.jhep.2018.08.011.
  139. Long MT, Noureddin M, Lim JK. AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review. Gastroenterology. 2022;163(3):764–774.e1. https://doi.org/10.1053/j.gastro.2022.06.023.
  140. Francque SM, Marchesini G, Kautz A, Walmsley M, Dorner R, Lazarus JV et al. Non-alcoholic fatty liver disease: A patient guideline. JHEP Rep. 2021;3(5):100322. https://doi.org/10.1016/j.jhepr.2021.100322.
  141. Jarvis H, O’Keefe H, Craig D, Stow D, Hanratty B, Anstee QM. Does moderate alcohol consumption accelerate the progression of liver disease in NAFLD? A systematic review and narrative synthesis. BMJ Open. 2022;12(1):e049767. https://doi.org/10.1136/bmjopen-2021-049767.
  142. Di Ciaula A, Bonfrate L, Krawczyk M, Frühbeck G, Portincasa P. Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis. Int J Mol Sci. 2022;23(5):2636. https://doi.org/10.3390/ijms23052636.
  143. Long MT, Massaro JM, Hoffmann U, Benjamin EJ, Naimi TS. Alcohol Use Is Associated With Hepatic Steatosis Among Persons With Presumed Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2020;18(8):1831–1841.e5. https://doi.org/10.1016/j.cgh.2019.11.022.
  144. El Hadi H, Di Vincenzo A, Vettor R, Rossato M. Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease. Int J Mol Sci. 2019;20(9):2215. https://doi.org/10.3390/ijms20092215.
  145. Lizardi-Cervera J, Aguilar-Zapata D. Nonalcoholic fatty liver disease and its association with cardiovascular disease. Ann Hepatol. 2009;8(Suppl. 1):S40–43. https://doi.org/10.1016/S1665-2681(19)31825-3.
  146. Angulo P, Kleiner DE, Dam-Larsen S, Adams LA, Bjornsson ES, Charatcharoenwitthaya P et al. Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2015;149(2):389–397.e10. https://doi.org/10.1053/j.gastro.2015.04.043.
  147. Kwo PY, Cohen SM, Lim JK. ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. Am J Gastroenterol. 2017;112(1):18–35. https://doi.org/10.1038/ajg.2016.517.
  148. Kim HC, Nam CM, Jee SH, Han KH, Oh DK, Suh I. Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study. BMJ. 2004;328(7446):983. https://doi.org/10.1136/bmj.38050.593634.63.
  149. Lee TH, Kim WR, Benson JT, Therneau TM, Melton LJ 3rd. Serum aminotransferase activity and mortality risk in a United States community. Hepatology. 2008;47(3):880–887. https://doi.org/10.1002/hep.22090.
  150. Ruhl CE, Everhart JE. Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population. Gastroenterology. 2009;136(2):477–485.e11. https://doi.org/10.1053/j.gastro.2008.10.052.
  151. Ioannou GN, Weiss NS, Boyko EJ, Mozaffarian D, Lee SP. Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States. Hepatology. 2006;43(5):1145–1151. https://doi.org/10.1002/hep.21171.
  152. Buzzetti E, Linden A, Best LM, Madden AM, Roberts D, Chase TJG et al. Lifestyle modifications for nonalcohol-related fatty liver disease: a network meta-analysis. Cochrane Database Syst Rev. 2021;6(6):CD013156. https://doi.org/10.1002/14651858.CD013156.pub2.
  153. Komolafe O, Buzzetti E, Linden A, Best LM, Madden AM, Roberts D et al. Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis. Cochrane Database Syst Rev. 2021;7(7):CD013157. https://doi.org/10.1002/14651858.CD013157.pub2.
  154. Romero-Gómez M, Zelber-Sagi S, Trenell M. Treatment of NAFLD with diet, physical activity and exercise. J Hepatol. 2017;67(4):829–846. https://doi.org/10.1016/j.jhep.2017.05.016.
  155. Peng L, Wang J, Li F. Weight reduction for non-alcoholic fatty liver disease. Cochrane Database Syst Rev. 2011;(6):CD003619. https://doi.org/10.1002/14651858.CD003619.pub3.
  156. Xiang Z, Chen YP, Ma KF, Ye YF, Zheng L, Yang YD et al. The role of ursodeoxycholic acid in non-alcoholic steatohepatitis: a systematic review. BMC Gastroenterol. 2013;13:140. https://doi.org/10.1186/1471-230X-13-140.
  157. Simental-Mendía M, Sánchez-García A, Simental-Mendía LE. Effect of ursodeoxycholic acid on liver markers: A systematic review and meta-analysis of randomized placebo-controlled clinical trials. Br J Clin Pharmacol. 2020;86(8):1476–1488. https://doi.org/10.1111/bcp.14311.
  158. Laurin J, Lindor KD, Crippin JS, Gossard A, Gores GJ, Ludwig J et al. Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study. Hepatology. 1996;23(6):1464–1467. https://doi.org/10.1002/hep.510230624.
  159. Ozel Coskun BD, Yucesoy M, Gursoy S, Baskol M, Yurci A, Yagbasan A et al. Effects of ursodeoxycholic acid therapy on carotid intima media thickness, apolipoprotein A1, apolipoprotein B, and apolipoprotein B/A1 ratio in nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol. 2015;27(2):142–149. https://doi.org/10.1097/MEG.0000000000000264.
  160. Ratziu V, de Ledinghen V, Oberti F, Mathurin P, Wartelle-Bladou C, Renou C et al. A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis. J Hepatol. 2011;54(5):1011–1019. https://doi.org/10.1016/j.jhep.2010.08.030.
  161. Павлов ЧС, Варганова ДЛ, Семенистая МЧ, Кузнецова ЕА, Усанова АА, Свистунов АА. Урсодезоксихолевая кислота: эффективность и безопасность в лечении неалкогольной жировой болезни печени (мета-анализ). Вестник Российской академии медицинских наук. 2018;73(5):294–305. https://doi.org/10.15690/vramn975
  162. Zhang W, Tang Y, Huang J, Hu H. Efficacy of ursodeoxycholic acid in nonalcoholic fatty liver disease: An updated meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2020;29(4):696–705. https://doi.org/10.6133/apjcn.202012_29(4).0004.
  163. Lin X, Mai M, He T, Huang H, Zhang P, Xia E, Guo H. Efficiency of ursodeoxycholic acid for the treatment of nonalcoholic steatohepatitis: A systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2022;16(6):537–545. https://doi.org/10.1080/17474124.2022.2083605.
  164. Nadinskaia M, Maevskaya M, Ivashkin V, Kodzoeva K, Pirogova I, Chesnokov E et al. Ursodeoxycholic acid as a means of preventing atherosclerosis, steatosis and liver fibrosis in patients with nonalcoholic fatty liver disease. World J Gastroenterol. 2021;27(10):959–975. https://doi.org/10.3748/wjg.v27.i10.959.
  165. Byrnes K, Blessinger S, Bailey NT, Scaife R, Liu G, Khambu B. Therapeutic regulation of autophagy in hepatic metabolism. Acta Pharm Sin B. 2022;12(1):33–49. https://doi.org/10.1016/j.apsb.2021.07.021.
  166. Decuypere JP, Parys JB, Bultynck G. Regulation of the autophagic bcl-2/beclin 1 interaction. Cells. 2012;1(3):284–312. https://doi.org/10.3390/cells1030284.
  167. Carino A, Biagioli M, Marchianò S, Fiorucci C, Zampella A, Monti MC et al. Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864(10):1422–1437. https://doi.org/10.1016/j.bbalip.2019.07.006.
  168. Marchianò S, Biagioli M, Roselli R, Zampella A, Di Giorgio C, Bordoni M et al. Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867(11):159218. https://doi.org/10.1016/j.bbalip.2022.159218.
  169. Karedath J, Javed H, Ahsan Talpur F, Lal B, Kumari A, Kivan H et al. Effect of Vitamin E on Clinical Outcomes in Patients With Non-alcoholic Fatty Liver Disease: A Meta-Analysis. Cureus. 2022;14(12):e32764. https://doi.org/10.7759/cureus.32764.
  170. Bril F, Biernacki DM, Kalavalapalli S, Lomonaco R, Subbarayan SK, Lai J et al. Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care. 2019;42(8):1481–1488. https://doi.org/10.2337/dc19-0167.
  171. Xu R, Tao A, Zhang S, Deng Y, Chen G. Association between vitamin E and non-alcoholic steatohepatitis: a meta-analysis. Int J Clin Exp Med. 2015;8(3):3924–3934. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443128/.
  172. Mazhar IJ, Yasir M, Sarfraz S, Shlaghya G, Narayana SH, Mushtaq U et al. Vitamin E and Pioglitazone: A Comprehensive Systematic Review of Their Efficacy in Non-alcoholic Fatty Liver Disease. Cureus. 2023;15(8):e43635. https://doi.org/10.7759/cureus.43635.
  173. Vilar-Gomez E, Vuppalanchi R, Gawrieh S, Ghabril M, Saxena R, Cummings OW, Chalasani N. Vitamin E Improves Transplant-Free Survival and Hepatic Decompensation Among Patients With Nonalcoholic Steatohepatitis and Advanced Fibrosis. Hepatology. 2020;71(2):495–509. https://doi.org/10.1002/hep.30368.
  174. European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64(6):1388–1402. https://doi.org/10.1016/j.jhep.2015.11.004.
  175. Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328–357. https://doi.org/10.1002/hep.29367.
  176. Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362(18):1675–1685. https://doi.org/10.1056/NEJMoa0907929.
  177. Ando Y, Jou JH. Nonalcoholic Fatty Liver Disease and Recent Guideline Updates. Clin Liver Dis (Hoboken). 2021;17(1):23–28. https://doi.org/10.1002/cld.1045.
  178. Bjelakovic G, Nikolova D, Gluud C. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS ONE. 2013;8(9):e74558. https://doi.org/10.1371/journal.pone.0074558.
  179. Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142(1):37–46. https://doi.org/10.7326/0003-4819-142-1-200501040-00110.
  180. Curtis AJ, Bullen M, Piccenna L, McNeil JJ. Vitamin E supplementation and mortality in healthy people: a meta-analysis of randomised controlled trials. Cardiovasc Drugs Ther. 2014;28(6):563–573. https://doi.org/10.1007/s10557-014-6560-7.
  181. Vivarelli F, Canistro D, Cirillo S, Papi A, Spisni E, Vornoli A et al. Co-carcinogenic effects of vitamin E in prostate. Sci Rep. 2019;9(1):11636. https://doi.org/10.1038/s41598-019-48213-1.
  182. Podszun M, Frank J. Vitamin E-drug interactions: molecular basis and clinical relevance. Nutr Res Rev. 2014;27(2):215–231. https://doi.org/10.1017/S0954422414000146.
  183. Noureddin M, Sander-Struckmeier S, Mato JM. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review. World J Hepatol. 2020;12(2):46–63. https://doi.org/10.4254/wjh.v12.i2.46.
  184. Райхельсон КЛ, Кондрашина ЭА. Адеметионин в лечении повышенной утомляемости/слабости при заболеваниях печени: систематический обзор. Терапевтический архив. 2019;91(2):134–142. https://doi.org/10.26442/00403660.2019.02.000130.
  185. Барановский А.Ю., Райхельсон К.Л., Марченко Н.В. Применение S-аденозилметионина (Гептрала®) в терапии больных неалкогольным стеатогепатитом. Клинические перспективы гастроэнтерологии, гепатологии, 2010;9(1):3–10. Режим доступа: https://www.elibrary.ru/kzgaan.
  186. Shankar R, Virukalpattigopalratnam MP, SinghT.Heptral® (Ademetionine) in Intrahepatic Cholestasis due to Chronic Non-Alcoholic Liver Disease: Subgroup Analysis of Results of a Multicentre Observational Study in India. J Clin Exp Hepatol. 2014;4(Suppl. 2):S33. https://doi.org/10.1016/j.jceh.2014.02.071.
  187. Li H, Liu NN, Peng ZG. Effect of bicyclol on blood biomarkers of NAFLD: a systematic review and meta-analysis. BMJ Open. 2020;10(12):e039700. https://doi.org/10.1136/bmjopen-2020-039700.
  188. Маевская МВ, Луньков ВД, Гейвандова НИ, Пальгова ЛК, Пирогова ИЮ, Прашнова МК и др. Бициклол в лечении пациентов с хроническими диффузными заболеваниями печени. Медицинский совет. 2020;(15):78–89. https://doi.org/10.21518/2079-701X-2020-15-78-89.
  189. Pan SY, Dong H, Yu ZL, Zhao XY, Xiang CJ, Wang H et al. Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice. J Pharm Pharmacol. 2007;59(12):1657–1662. https://doi.org/10.1211/jpp.59.12.0007.
  190. Pan SY, Yu ZL, Dong H, Xiang CJ, Fong WF, Ko KM. Ethanol extract of fructus schisandrae decreases hepatic triglyceride level in mice fed with a high fat/cholesterol diet, with attention to acute toxicity. Evid Based Complement Alternat Med. 2011:729412. https://doi.org/10.1093/ecam/nep070.
  191. Zhao W, Yan Y, Xiao Z, Wang M, Xu M, Wang Z et al. Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways. Biomed Pharmacother. 2021;141:111874. https://doi.org/10.1016/j.biopha.2021.111874.
  192. Пирогова ИЮ, Яковлева СВ, Неуймина ТВ, Синицын СП, Чулков ВС, Шамаева ТН. Эффективность и безопасность Бициклола при неалкогольной жировой болезни печени: результаты когортного исследования. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2018;28(4):66–75. https://doi.org/10.22416/1382-4376-2018-28-4-66-75.
  193. Оковитый СВ, Приходько ВА, Безбородкина НН, Кудрявцев БН. Гепатопротекторы: руководство для врачей. 2-е изд. М.: ГЭОТАР-Медиа; 2022. 240 с. https://doi.org/10.33029/9704-6689-6-LIV-1-240.
  194. Семисtрин ВА, Каракозов АГ, Малькута МА, Золотарtва ЛА, Левченко ОБ, Калягин ИЕ, Еремин М.Н. Оценка эффективности гепатопротективной монотерапии неалкогольной жировой болезни печени в стадии стеатогепатита препаратом на основе янтарной кислоты и метионина. Терапевтический архив. 2016;88(2):58–63. https://doi.org/10.17116/terarkh201688258-63.
  195. Стельмах ВВ, Козлов ВК, Баранов ВЛ, Латария ЭЛ, Некрасова АС. Энерготропная патогенетически ориентированная терапия сукцинатсодержащими препаратами при неалкогольной жировой болезни печени: перспективы клинического применения. Медицинский алфавит. 2013;1(2):38–44. Режим доступа: https://www.elibrary.ru/rmxlrt.
  196. Дударенко СВ, Коваленко АЛ, Прокопенко СМ, Белогурова ЕВ. Применение ремаксола в терапии метаболического синдрома у пациентов с неалкогольным стеатогепатитом и сахарным диабетом 2 типа. Экспериментальная и клиническая гастроэнтерология. 2016;(6):89–94. Режим доступа: https://www.nogr.org/jour/article/view/221.
  197. Шиповская АА, Дуданова ОП. Внутрипеченочный холестаз при неалкогольной жировой болезни печени. Терапевтический архив. 2018;90(2):69–74. https://doi.org/10.26442/terarkh201890269-74.
  198. Pennisi G, Pipitone RM, Grimaudo S, Spatola F, Di Martino V, Cammà C et al. A cholestatic pattern predicts liver outcomes in patients with nonalcoholic fatty liver disease. Dig Liver Dis. 2021;53(Suppl. 1):S27. https://doi.org/10.1016/j.dld.2020.12.069.
  199. Широкова ЕН. Внутрипеченочный холестаз при неалкогольной жировой болезни печени: патогенез и роль адеметионина в терапии. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2023;33(2):79–86. https://doi.org/10.22416/1382-4376-2023-33-2-79-86.
  200. Anstee QM, Day CP. S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility. J Hepatol. 2012;57(5):1097–1109. https://doi.org/10.1016/j.jhep.2012.04.041.
  201. Butterworth RF, Kircheis G, Hilger N, McPhail MJW. Efficacy of l-Ornithine l-Aspartate for the Treatment of Hepatic Encephalopathy and Hyperammonemia in Cirrhosis: Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Clin Exp Hepatol. 2018;8(3):301–313. https://doi.org/10.1016/j.jceh.2018.05.004.
  202. Ермолова ТВ, Ермолов СЮ, Сологуб ТВ, Карев ВЕ, Добкес АЛ, Апресян АГ. Нарушения портопеченочной гемодинамики при хронических заболеваниях печени на начальных стадиях фиброза и их коррекция. Фарматека. 2016;(15):58–66. Режим доступа: https://pharmateca.ru/ru/archive/article/33748.
  203. Зыкина ЕЮ, Симонова ЖГ. Гипераммониемия у пациентов со стабильной стенокардией и неалкогольной жировой болезнью печени на стадии стеатоза. Экспериментальная и клиническая гастроэнтерология. 2023;(8):57–65. https://doi.org/10.31146/1682-8658-ecg-216-8-57-65.
  204. Гаранина ЕВ. Влияние курсового приема L-орнитин- L-аспартата на фиброз и стеатоз печени у больных ассоциированной с нарушениями метаболизма жировой болезнью печени (неалкогольной жировой болезнью печени), имеющих гипераммониемию. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2021;31(4):31–36. https://doi.org/10.22416/1382-4376-2021-31-4-31-36.
  205. Kaiser S, Gerok W, Häussinger D. Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonaemia in chronic liver disease. Eur J Clin Invest. 1988;18(5):535–542. https://doi.org/10.1111/j.1365-2362.1988.tb01053.x.
  206. De Chiara F, Heebøll S, Marrone G, Montoliu C, Hamilton-Dutoit S, Ferrandez A et al. Urea cycle dysregulation in non-alcoholic fatty liver disease. J Hepatol. 2018;69(4):905–915. https://doi.org/10.1016/j.jhep.2018.06.023.
  207. Алексеенко СА, Агеева ЕА, Полковникова ОП. Современные подходы к диагностике и лечению гипераммониемии у пациентов с хроническими заболеваниями печени на доцирротической стадии. РМЖ. Медицинское обозрение. 2018;2(7-1):19–23. Режим доступа: https://www.rmj.ru/articles/gastroenterologiya/Sovremennye_podhody_k_diagnostike_i_lecheniyu_giperammoniemii_u_pacientov_s_hronicheskimi_zabolevaniyami_pecheni_na_docirroticheskoy_stadii/.
  208. Tian LY, Lu LG, Tang CW, Xie Y, Luo HS, Tan SY et al. Aspartate-ornithine granules in the treatment of nonalcoholic steatohepatitis: a multiple-dose parallel controlled clinical trial. Zhonghua Gan Zang Bing Za Zhi. 2013;21(7):528–532. (In Chinese) https://doi.org/10.3760/cma.j.issn.1007-3418.2013.07.013.
  209. Pichon C, Nachit M, Gillard J, Vande Velde G, Lanthier N, Leclercq IA. Impact of L-ornithine L-aspartate on non-alcoholic steatohepatitis-associated hyperammonemia and muscle alterations. Front Nutr. 2022;9:1051157. https://doi.org/10.3389/fnut.2022.1051157.
  210. Prikhodko VA, Sysoev YuI, Poveryaeva MA, Bunyat AV, Karev VE, Ivkin DYu et al. Effects of empagliflozin and L-ornithine L-aspartate on behavior, cognitive functions, and physical performance in mice with experimentally induced steatohepatitis. Bulletin of Russian State Medical University. 2020;(3):49–57. https://doi.org/10.24075/brsmu.2020.034.
  211. Оковитый СВ, Райхельсон КЛ, Приходько ВА. Комбинированная гепатопротекторная фармакотерапия заболеваний печени. Экспериментальная и клиническая гастроэнтерология. 2022;(7):5–20. https://doi.org/10.31146/1682-8658-ecg-203-7-5-20.
  212. Dufour JF, Oneta CM, Gonvers JJ, Bihl F, Cerny A, Cereda JM et al. Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin e in nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2006;4(12):1537–1543. https://doi.org/10.1016/j.cgh.2006.09.025.
  213. Pietu F, Guillaud O, Walter T, Vallin M, Hervieu V, Scoazec JY, Dumortier J. Ursodeoxycholic acid with vitamin E in patients with nonalcoholic steatohepatitis: long-term results. Clin Res Hepatol Gastroenterol. 2012;36(2):146–155. https://doi.org/10.1016/j.clinre.2011.10.011.
  214. Balmer ML, Siegrist K, Zimmermann A, Dufour JF. Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. Liver Int. 2009;29(8):1184–1188. https://doi.org/10.1111/j.1478-3231.2009.02037.x.
  215. Thomsen MN, Skytte MJ, Samkani A, Carl MH, Weber P, Astrup A et al. Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: a randomised controlled trial. Diabetologia. 2022;65(3):506–517. https://doi.org/10.1007/s00125-021-05628-8.
  216. Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L et al. Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. Gastroenterology. 2015;149(2):367–378.e5. https://doi.org/10.1053/j.gastro.2015.04.005.
  217. Wong C, Lee MH, Yaow CYL, Chin YH, Goh XL, Ng CH et al. Glucagon-Like Peptide-1 Receptor Agonists for Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: A Meta-Analysis. Front Endocrinol (Lausanne). 2021;12:609110. https://doi.org/10.3389/fendo.2021.609110.
  218. Fan S, Shi X, Yao J, Zhong M, Feng P. The efficacy of glucagon-like peptide 1 receptor agonists in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials. Rev Esp Enferm Dig. 2020;112(8):627–635. https://doi.org/10.17235/reed.2020.6392/2019.
  219. Newsome PN, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V et al. A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis. N Engl J Med. 2021;384(12):1113–1124. https://doi.org/10.1056/NEJMoa2028395.
  220. Zhu K, Kakkar R, Chahal D, Yoshida EM, Hussaini T. Efficacy and safety of semaglutide in non-alcoholic fatty liver disease. World J Gastroenterol. 2023;29(37):5327–5338. https://doi.org/10.3748/wjg.v29.i37.5327.
  221. Bandyopadhyay S, Das S, Samajdar SS, Joshi SR. Role of semaglutide in the treatment of nonalcoholic fatty liver disease or non-alcoholic steatohepatitis: A systematic review and meta-analysis. Diabetes Metab Syndr. 2023;17(10):102849. https://doi.org/10.1016/j.dsx.2023.102849.
  222. Gu Y, Sun L, Zhang W, Kong T, Zhou R, He Y et al. Comparative efficacy of 5 sodium-glucose cotransporter protein-2 (SGLT-2) inhibitor and 4 glucagon-like peptide-1 (GLP-1) receptor agonist drugs in non-alcoholic fatty liver disease: A GRADE-assessed systematic review and network meta-analysis of randomized controlled trials. Front Pharmacol. 2023;14:1102792. https://doi.org/10.3389/fphar.2023.1102792.
  223. Parab P, Chaudhary P, Mukhtar S, Moradi A, Kodali A, Okoye C et al. Role of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Cardiovascular Risk Management in Patients With Type 2 Diabetes Mellitus: A Systematic Review. Cureus. 2023;15(9):e45487. https://doi.org/10.7759/cureus.45487.
  224. Banerjee M, Pal R, Mukhopadhyay S, Nair K. GLP-1 Receptor Agonists and Risk of Adverse Cerebrovascular Outcomes in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Clin Endocrinol Metab. 2023;108(7):1806–1812. https://doi.org/10.1210/clinem/dgad076.
  225. Gomes DA, Presume J, de Araújo Gonçalves P, Almeida MS, Mendes M, Ferreira J. Association Between the Magnitude of Glycemic Control and Body Weight Loss With GLP-1 Receptor Agonists and Risk of Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-analyses of Randomized Diabetes Cardiovascular Outcomes Trials. Cardiovasc Drugs Ther. 2024. https://doi.org/10.1007/s10557-024-07547-3. Epub ahead of print.
  226. Cusi K, Orsak B, Bril F, Lomonaco R, Hecht J, Ortiz-Lopez C et al. Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus: A Randomized Trial. Ann Intern Med. 2016;165(5):305–315. https://doi.org/10.7326/M15-1774.
  227. Musso G, Cassader M, Paschetta E, Gambino R. Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis: A Meta-analysis. JAMA Intern Med. 2017;177(5):633–640. https://doi.org/10.1001/jamainternmed.2016.9607.
  228. Ndakotsu A, Vivekanandan G. The Role of Thiazolidinediones in the Amelioration of Nonalcoholic Fatty Liver Disease: A Systematic Review. Cureus. 2022;14(5):e25380. https://doi.org/10.7759/cureus.25380.
  229. Budd J, Cusi K. Role of Agents for the Treatment of Diabetes in the Management of Nonalcoholic Fatty Liver Disease. Curr Diab Rep. 2020;20(11):59. https://doi.org/10.1007/s11892-020-01349-1.
  230. Государственный реестр лекарственных средств. Пиоглар. Номер ЛС-001671, дата регистрации 16.07.2011. Режим доступа: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=66ecaf50-2ba6-41a8-848f-de7e5b8c9220.
  231. Gautam A, Agrawal PK, Doneria J, Nigam A. Effects of Canagliflozin on Abnormal Liver Function Tests in Patients of Type 2 Diabetes with Non-Alcoholic Fatty Liver Disease. J Assoc Physicians India. 2018;66(8):62–66. Available at: https://pubmed.ncbi.nlm.nih.gov/31324087/.
  232. Приходько ВА, Оковитый СВ, Куликов АН. Глифлозины при неалкогольной жировой болезни печени: перспективы применения за границами диабета, кардио- и нефропротекции. Терапия. 2023;9(7):130–141. https://doi.org/10.18565/therapy.2023.7.130-141.
  233. Wei Q, Xu X, Guo L, Li J, Li L. Effect of SGLT2 Inhibitors on Type 2 Diabetes Mellitus With Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials. Front Endocrinol (Lausanne). 2021;12:635556. https://doi.org/10.3389/fendo.2021.635556.
  234. Mo M, Huang Z, Liang Y, Liao Y, Xia N. The safety and efficacy evaluation of sodium-glucose co-transporter 2 inhibitors for patients with non-alcoholic fatty liver disease: An updated meta-analysis. Dig Liver Dis. 2022;54(4):461–468. https://doi.org/10.1016/j.dld.2021.08.017.
  235. Jin Z, Yuan Y, Zheng C, Liu S, Weng H. Effects of sodium-glucose co-transporter 2 inhibitors on liver fibrosis in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: An updated meta-analysis of randomized controlled trials. J Diabetes Complications. 2023;37(8):108558. https://doi.org/10.1016/j.jdiacomp.2023.108558.
  236. Ong Lopez AMC, Pajimna JAT. Efficacy of sodium glucose cotransporter 2 inhibitors on hepatic fibrosis and steatosis in non-alcoholic fatty liver disease: an updated systematic review and meta-analysis. Sci Rep. 2024;14(1):2122. https://doi.org/10.1038/s41598-024-52603-5.
  237. Sánchez-García A, Sahebkar A, Simental-Mendía M, Simental-Mendía LE. Effect of ursodeoxycholic acid on glycemic markers: A systematic review and meta-analysis of clinical trials. Pharmacol Res. 2018;135:144–149. https://doi.org/10.1016/j.phrs.2018.08.008.
  238. Elhini SH, Wahsh EA, Elberry AA, El Ameen NF, Abdelfadil Saedii A, Refaie SM et al. The Impact of an SGLT2 Inhibitor versus Ursodeoxycholic Acid on Liver Steatosis in Diabetic Patients. Pharmaceuticals (Basel). 2022;15(12):1516. https://doi.org/10.3390/ph15121516.
  239. Houttu V, Csader S, Nieuwdorp M, Holleboom AG, Schwab U. Dietary Interventions in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. Front Nutr. 2021;8:716783. https://doi.org/10.3389/fnut.2021.716783.
  240. Koutoukidis DA, Astbury NM, Tudor KE, Morris E, Henry JA, Noreik M et al. Association of Weight Loss Interventions With Changes in Biomarkers of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. JAMA Intern Med. 2019;179(9):1262–1271. https://doi.org/10.1001/jamainternmed.2019.2248.
  241. Ezpeleta M, Gabel K, Cienfuegos S, Kalam F, Lin S, Pavlou V et al. Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial. Cell Metab. 2023;35(1):56–70.e3. https://doi.org/10.1016/j.cmet.2022.12.001.
  242. Haufe S, Engeli S, Kast P, Böhnke J, Utz W, Haas V et al. Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology. 2011;53(5):1504–1514. https://doi.org/10.1002/hep.24242.
  243. Asrih M, Jornayvaz FR. Diets and nonalcoholic fatty liver disease: the good and the bad. Clin Nutr. 2014;33(2):186–190. https://doi.org/10.1016/j.clnu.2013.11.003.
  244. Lemstra M, Bird Y, Nwankwo C, Rogers M, Moraros J. Weight loss intervention adherence and factors promoting adherence: a meta-analysis. Patient Prefer Adherence. 2016;10:1547–1559. https://doi.org/10.2147/PPA.S103649.
  245. Scragg J, Hallsworth K, Taylor G, Cassidy S, Haigh L, Boyle M et al. Factors associated with engagement and adherence to a low-energy diet to promote 10% weight loss in patients with clinically significant non-alcoholic fatty liver disease. BMJ Open Gastroenterol. 2021;8(1):e000678. https://doi.org/10.1136/bmjgast-2021-000678.
  246. Armstrong MJ, Gaunt P, Aithal GP, Barton D, Hull D, Parker R et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet. 2016;387(10019):679–690. https://doi.org/10.1016/S0140-6736(15)00803-X.
  247. Vilsbøll T, Christensen M, Junker AE, Knop FK, Gluud LL. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ. 2012;344:d7771. https://doi.org/10.1136/bmj.d7771.
  248. Stokes CS, Gluud LL, Casper M, Lammert F. Ursodeoxycholic acid and diets higher in fat prevent gallbladder stones during weight loss: a meta-analysis of randomized controlled trials. Clin Gastroenterol Hepatol. 2014;12(7):1090–1100.e2. https://doi.org/10.1016/j.cgh.2013.11.031.
  249. Fearon NM, Kearns EC, Kennedy CA, Conneely JB, Heneghan HM. The impact of ursodeoxycholic acid on gallstone disease after bariatric surgery: a meta-analysis of randomized control trials. Surg Obes Relat Dis. 2022;18(1):77–84. https://doi.org/10.1016/j.soard.2021.10.004.
  250. Mulliri A, Menahem B, Alves A, Dupont B. Ursodeoxycholic acid for the prevention of gallstones and subsequent cholecystectomy after bariatric surgery: a meta-analysis of randomized controlled trials. J Gastroenterol. 2022;57(8):529–539. https://doi.org/10.1007/s00535-022-01886-4.
  251. Johansson K, Sundström J, Marcus C, Hemmingsson E, Neovius M. Risk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study. Int J Obes (Lond). 2014;38(2):279–284. https://doi.org/10.1038/ijo.2013.83.
  252. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones. J Hepatol. 2016;65(1):146–181. https://doi.org/10.1016/j.jhep.2016.03.005.
  253. Uy MC, Talingdan-Te MC, Espinosa WZ, Daez ML, Ong JP. Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis. Obes Surg. 2008;18(12):1532–1538. https://doi.org/10.1007/s11695-008-9587-7.
  254. Dongiovanni P, Petta S, Mannisto V, Mancina RM, Pipitone R, Karja V et al. Statin use and non-alcoholic steatohepatitis in at risk individuals. J Hepatol. 2015;63(3):705–712. https://doi.org/10.1016/j.jhep.2015.05.006.
  255. Zhou H, Toshiyoshi M, Zhao W, Zhao Y, Zhao Y. Statins on nonalcoholic fatty liver disease: A systematic review and meta-analysis of 14 RCTs. Medicine (Baltimore). 2023;102(26):e33981. https://doi.org/10.1097/MD.0000000000033981.
  256. Pastori D, Sciacqua A, Marcucci R, Del Ben M, Baratta F, Violi F, Pignatelli P. Non-alcoholic fatty liver disease (NAFLD), metabolic syndrome and cardiovascular events in atrial fibrillation. A prospective multicenter cohort study. Intern Emerg Med. 2021;16(8):2063–2068. https://doi.org/10.1007/s11739-021-02682-3.
  257. Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111–188. https://doi.org/10.1093/eurheartj/ehz455.
  258. Pastori D, Pani A, Di Rocco A, Menichelli D, Gazzaniga G, Farcomeni A et al. Statin liver safety in non-alcoholic fatty liver disease: A systematic review and metanalysis. Br J Clin Pharmacol. 2022;88(2):441–451. https://doi.org/10.1111/bcp.14943.
  259. Abdallah M, Brown L, Provenza J, Tariq R, Gowda S, Singal AK. Safety and efficacy of dyslipidemia treatment in NAFLD patients: a meta-analysis of randomized controlled trials. Ann Hepatol. 2022;27(6):100738. https://doi.org/10.1016/j.aohep.2022.100738.
  260. Athyros VG, Boutari C, Stavropoulos K, Anagnostis P, Imprialos KP, Doumas M, Karagiannis A. Statins: An Under-Appreciated Asset for the Prevention and the Treatment of NAFLD or NASH and the Related Cardiovascular Risk. Curr Vasc Pharmacol. 2018;16(3):246–253. https://doi.org/10.2174/1570161115666170621082910.
  261. Torres-Peña JD, Martín-Piedra L, Fuentes-Jiménez F. Statins in Non-alcoholic Steatohepatitis. Front Cardiovasc Med. 2021;8:777131. https://doi.org/10.3389/fcvm.2021.777131.
  262. Aithal GP, Watkins PB, Andrade RJ, Larrey D, Molokhia M, Takikawa H e al. Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther. 2011;89(6):806–815. https://doi.org/10.1038/clpt.2011.58.
  263. Марцевич СЮ, Кутишенко НП, Дроздова ЛЮ, Лерман ОВ, Невзорова ВА, Резник ИИ и др. Исследование РАКУРС: повышение эффективности и безопасности терапии статинами у больных с заболеваниями печени, желчного пузыря и/или желчевыводящих путей с помощью урсодеоксихолевой кислоты. Терапевтический архив. 2014;86(12):48–52. https://doi.org/10.17116/terarkh2014861248-52.
  264. Nadinskaya M, Martsevich S, Kutishenko N, Balashov I, Lerman O. P0624 Ursodeoxycholic acid influence on efficacy and safety of statin therapy in patients with high risk of cardiovascular events and nonalcoholic fatty liver disease: the RACURS study (post-hoc analysis). United European Gastroenterol J. 2015;3(Suppl. 5): P0624. https://doi.org/10.1177/2050640615601623.
  265. Cabezas Gelabert R. Efecto del ácido ursodesoxicólico combinado con estatinas para el tratamiento de la hipercolesterolemia: ensayo clínico prospectivo. Rev Clin Esp. 2004;204(12):632–635. https://doi.org/10.1016/s0014-2565(04)71566-0.
  266. Seo SH, Lee DH, Lee YS, Cho KJ, Park HJ, Lee HW et al. Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model. Gastroenterol Rep (Oxf). 2022;10:goac037. https://doi.org/10.1093/gastro/goac037.
  267. Nakade Y, Murotani K, Inoue T, Kobayashi Y, Yamamoto T, Ishii N et al. Ezetimibe for the treatment of non-alcoholic fatty liver disease: A meta-analysis. Hepatol Res. 2017;47(13):1417–1428. https://doi.org/10.1111/hepr.12887.
  268. Lee HY, Jun DW, Kim HJ, Oh H, Saeed WK, Ahn H et al. Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis. Korean J Intern Med. 2019;34(2):296–304. https://doi.org/10.3904/kjim.2017.194.
  269. Cho Y, Rhee H, Kim YE, Lee M, Lee BW, Kang ES et al. Ezetimibe combination therapy with statin for non-alcoholic fatty liver disease: an open-label randomized controlled trial (ESSENTIAL study). BMC Med. 2022;20(1):93. https://doi.org/10.1186/s12916-022-02288-2.
  270. Lee CH, Fu Y, Yang SJ, Chi CC. Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Non-Alcoholic Fatty Liver: A Systematic Review and Meta-Analysis. Nutrients. 2020;12(9):2769. https://doi.org/10.3390/nu12092769.
  271. Musazadeh V, Karimi A, Malekahmadi M, Ahrabi SS, Dehghan P. Omega-3 polyunsaturated fatty acids in the treatment of non-alcoholic fatty liver disease: An umbrella systematic review and meta-analysis. Clin Exp Pharmacol Physiol. 2023;50(5):327–334. https://doi.org/10.1111/1440-1681.13750.
  272. Yan JH, Guan BJ, Gao HY, Peng XE. Omega-3 polyunsaturated fatty acid supplementation and non-alcoholic fatty liver disease: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2018;97(37):e12271. https://doi.org/10.1097/MD.0000000000012271.
  273. Maciejewska-Markiewicz D, Stachowska E, Hawryłkowicz V, Stachowska L, Prowans P. The Role of Resolvins, Protectins and Marensins in Non-Alcoholic Fatty Liver Disease (NAFLD). Biomolecules. 2021;11(7):937. https://doi.org/10.3390/biom11070937.
  274. Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB et al. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med. 2019;380(1):11–22. https://doi.org/10.1056/NEJMoa1812792.
  275. Sanyal AJ, Abdelmalek MF, Suzuki A, Cummings OW, Chojkier M. No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. Gastroenterology. 2014;147(2):377–384.e1. https://doi.org/10.1053/j.gastro.2014.04.046.
  276. Scorletti E, Bhatia L, McCormick KG, Clough GF, Nash K, Hodson L et al. Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome* study. Hepatology. 2014;60(4):1211–1221. https://doi.org/10.1002/hep.27289.
  277. Hilleman DE, Wiggins BS, Bottorff MB. Critical Differences Between Dietary Supplement and Prescription Omega-3 Fatty Acids: A Narrative Review. Adv Ther. 2020;37(2):656–670. https://doi.org/10.1007/s12325-019-01211-1.
  278. Fernández-Miranda C, Pérez-Carreras M, Colina F, López-Alonso G, Vargas C, Solís-Herruzo JA. A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease. Dig Liver Dis. 2008;40(3):200–205. https://doi.org/10.1016/j.dld.2007.10.002.
  279. Mahmoudi A, Moallem SA, Johnston TP, Sahebkar A. Liver Protective Effect of Fenofibrate in NASH/NAFLD Animal Models. PPAR Res. 2022:5805398. https://doi.org/10.1155/2022/5805398.
  280. Lawitz EJ, Bhandari BR, Ruane PJ, Kohli A, Harting E, Ding D et al. Fenofibrate Mitigates Hypertriglyceridemia in Nonalcoholic Steatohepatitis Patients Treated With Cilofexor/Firsocostat. Clin Gastroenterol Hepatol. 2023;21(1):143–152.e3. https://doi.org/10.1016/j.cgh.2021.12.044.
  281. Maev IV, Samsonov AA, Palgova LK, Pavlov CS, Shirokova EN, Vovk EI, Starostin KM. Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-life observational study from Russia. BMJ Open Gastroenterol. 2020;7(1):e000368. https://doi.org/10.1136/bmjgast-2019-000368.
  282. Dajani AI, Popovic B. Essential phospholipids for nonalcoholic fatty liver disease associated with metabolic syndrome: A systematic review and network meta-analysis. World J Clin Cases. 2020;8(21):5235–5249. https://doi.org/10.12998/wjcc.v8.i21.5235.
  283. Kuche K, Bhargavi N, Dora CP, Jain S. Drug-Phospholipid Complex – a Go Through Strategy for Enhanced Oral Bioavailability. AAPS PharmSciTech. 2019;20(2):43. https://doi.org/10.1208/s12249-018-1252-4.
  284. Оковитый СВ, Болотова ВЦ, Анисимова НА, Ивкин ДЮ, Титович ИА, Сысоев ЮИ, Напалкова СМ. Перспективы применения растительных извлечений для коррекции нарушений жирового и углеводного обмена. Фармация. 2020;69(2):17–22. https://doi.org/10.29296/25419218-2020-02-03.
  285. Dimakopoulou A, Sfikas G, Athyros V. PCSK9 administration ameliorates non alcoholic fatty disease in patients with heterozygous familial hyperlipidemia. Hell J Atheroscler. 2018;9:12. https://doi.org/10.23803/HJA.V9I2.175.G150.
  286. Rimbert A, Smati S, Dijk W, Le May C, Cariou B. Genetic Inhibition of PCSK9 and Liver Function. JAMA Cardiol. 2021;6(3):353–354. https://doi.org/10.1001/jamacardio.2020.5341.
  287. Jang HR, Kang D, Sinn DH, Gu S, Cho SJ, Lee JE et al. Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study. Sci Rep. 2018;8(1):4718. https://doi.org/10.1038/s41598-018-23014-0.
  288. Musso G, Gambino R, Tabibian JH, Ekstedt M, Kechagias S, Hamaguchi M et al. Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis. PLoS Med. 2014;11(7):e1001680. https://doi.org/10.1371/journal.pmed.1001680.
  289. Targher G, Chonchol M, Bertolini L, Rodella S, Zenari L, Lippi G et al. Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease. J Am Soc Nephrol. 2008;19(8):1564–1570. https://doi.org/10.1681/ASN.2007101155.
  290. Heda R, Yazawa M, Shi M, Bhaskaran M, Aloor FZ, Thuluvath PJ, Satapathy SK. Non-alcoholic fatty liver and chronic kidney disease: Retrospect, introspect, and prospect. World J Gastroenterol. 2021;27(17):1864–1882. https://doi.org/10.3748/wjg.v27.i17.1864.
  291. Monteillet L, Gjorgjieva M, Silva M, Verzieux V, Imikirene L, Duchampt A et al. Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context. Mol Metab. 2018;16:100–115. https://doi.org/10.1016/j.molmet.2018.07.006.
  292. Shimano H, Sato R. SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nat Rev Endocrinol. 2017;13(12):710–730. https://doi.org/10.1038/nrendo.2017.91.
  293. Marcuccilli M, Chonchol M. NAFLD and Chronic Kidney Disease. Int J Mol Sci. 2016;17(4):562. https://doi.org/10.3390/ijms17040562.
  294. Kwon SY, Park J, Park SH, Lee YB, Kim G, Hur KY et al. MAFLD and NAFLD in the prediction of incident chronic kidney disease. Sci Rep. 2023;13(1):1796. https://doi.org/10.1038/s41598-023-27762-6.
  295. Zhang X, Wong GL, Yip TC, Tse YK, Liang LY, Hui VW et al. Angiotensin-converting enzyme inhibitors prevent liver-related events in nonalcoholic fatty liver disease. Hepatology. 2022;76(2):469–482. https://doi.org/10.1002/hep.32294.
  296. Hirata T, Tomita K, Kawai T, Yokoyama H, Shimada A, Kikuchi M et al. Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY). Int J Endocrinol. 2013:587140. https://doi.org/10.1155/2013/587140.
  297. Georgescu EF, Georgescu M. Therapeutic options in non-alcoholic steatohepatitis (NASH). Are all agents alike? Results of a preliminary study. J Gastrointestin Liver Dis. 2007;16(1):39–46. Available at: https://www.jgld.ro/jgld/index.php/jgld/article/view/2007.1.6.
  298. Georgescu EF, Ionescu R, Niculescu M, Mogoanta L, Vancica L. Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis. World J Gastroenterol. 2009;15(8):942–954. https://doi.org/10.3748/wjg.15.942.
  299. Yokohama S, Yoneda M, Haneda M, Okamoto S, Okada M, Aso K et al. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology. 2004;40(5):1222–1225. https://doi.org/10.1002/hep.20420.
  300. Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y et al. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009;50(3):929–938. https://doi.org/10.1002/hep.23104.
  301. Ala M. SGLT2 Inhibition for Cardiovascular Diseases, Chronic Kidney Disease, and NAFLD. Endocrinology. 2021;162(12):bqab157. https://doi.org/10.1210/endocr/bqab157.
  302. Toyama T, Neuen BL, Jun M, Ohkuma T, Neal B, Jardine MJ et al. Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta-analysis. Diabetes Obes Metab. 2019;21(5):1237–1250. https://doi.org/10.1111/dom.13648.
  303. Sarafidis P, Ferro CJ, Morales E, Ortiz A, Malyszko J, Hojs R et al. SGLT-2 inhibitors and GLP-1 receptor agonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease. A consensus statement by the EURECA-m and the DIABESITY working groups of the ERA-EDTA. Nephrol Dial Transplant. 2019;34(2):208–230. https://doi.org/10.1093/ndt/gfy407.
  304. Musso G, Cassader M, Cohney S, De Michieli F, Pinach S, Saba F, Gambino R. Fatty Liver and Chronic Kidney Disease: Novel Mechanistic Insights and Therapeutic Opportunities. Diabetes Care. 2016;39(10):1830–1845. https://doi.org/10.2337/dc15-1182.
  305. Heerspink HJL, Stefánsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436–1446. https://doi.org/10.1056/NEJMoa2024816.
  306. Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR et al. Empagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2023;388(2):117–127. https://doi.org/10.1056/NEJMoa2204233.
  307. Palmer SC, Tendal B, Mustafa RA, Vandvik PO, Li S, Hao Q et al. Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials. BMJ. 2021;372:m4573. https://doi.org/10.1136/bmj.m4573.
  308. Greco EV, Russo G, Giandalia A, Viazzi F, Pontremoli R, De Cosmo S. GLP-1 Receptor Agonists and Kidney Protection. Medicina (Kaunas). 2019;55(6):233. https://doi.org/10.3390/medicina55060233.
  309. Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA et al. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2016;375(4):311–322. https://doi.org/10.1056/NEJMoa1603827.
  310. Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016;375(19):1834–1844. https://doi.org/10.1056/NEJMoa1607141.
  311. Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. Lancet. 2019;394(10193):121–130. https://doi.org/10.1016/S0140-6736(19)31149-3.
  312. Zhang Y, Jiang L, Wang J, Wang T, Chien C, Huang W et al. Network meta-analysis on the effects of finerenone versus SGLT2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and chronic kidney disease. Cardiovasc Diabetol. 2022;21(1):232. https://doi.org/10.1186/s12933-022-01676-5.
  313. Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980;55(7):434–438. Available at: https://pubmed.ncbi.nlm.nih.gov/7382552/.
  314. Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology. 1990;11(1):74–80. https://doi.org/10.1002/hep.1840110114.
  315. Ajmera V, Belt P, Wilson LA, Gill RM, Loomba R, Kleiner DE et al. Among Patients With Nonalcoholic Fatty Liver Disease, Modest Alcohol Use Is Associated With Less Improvement in Histologic Steatosis and Steatohepatitis. Clin Gastroenterol Hepatol. 2018;16(9):1511–1520.e5. https://doi.org/10.1016/j.cgh.2018.01.026.
  316. Kimura T, Tanaka N, Fujimori N, Sugiura A, Yamazaki T, Joshita S et al. Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fibrosis. World J Gastroenterol. 2018;24(13):1440–1450. https://doi.org/10.3748/wjg.v24.i13.1440.
  317. Younossi ZM, Stepanova M, Ong J, Yilmaz Y, Duseja A, Eguchi Y et al. Effects of Alcohol Consumption and Metabolic Syndrome on Mortality in Patients With Nonalcoholic and Alcohol-Related Fatty Liver Disease. Clin Gastroenterol Hepatol. 2019;17(8):1625–1633.e1. https://doi.org/10.1016/j.cgh.2018.11.033.
  318. Ekstedt M, Franzén LE, Holmqvist M, Bendtsen P, Mathiesen UL, Bodemar G, Kechagias S. Alcohol consumption is associated with progression of hepatic fibrosis in non-alcoholic fatty liver disease. Scand J Gastroenterol. 2009;44(3):366–374. https://doi.org/10.1080/00365520802555991.
  319. Sookoian S, Castaño GO, Pirola CJ. Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43 175 individuals. Gut. 2014;63(3):530–532. https://doi.org/10.1136/gutjnl-2013-305718.
  320. Cao G, Yi T, Liu Q, Wang M, Tang S. Alcohol consumption and risk of fatty liver disease: a meta-analysis. PeerJ. 2016;4:e2633. https://doi.org/10.7717/peerj.2633.
  321. Chang Y, Cho YK, Kim Y, Sung E, Ahn J, Jung HS et al. Nonheavy Drinking and Worsening of Noninvasive Fibrosis Markers in Nonalcoholic Fatty Liver Disease: A Cohort Study. Hepatology. 2019;69(1):64–75. https://doi.org/10.1002/hep.30170.
  322. Blomdahl J, Nasr P, Ekstedt M, Kechagias S. Moderate alcohol consumption is associated with significant fibrosis progression in NAFLD. Hepatol Commun. 2023;7(1):e0003. https://doi.org/10.1097/HC9.0000000000000003.
  323. Ивашкин ВТ, Жаркова МС, Корочанская НВ, Хлынов ИБ, Успенский ЮП. Фенотипы неалкогольной жировой болезни печени в различных регионах Российской Федерации, диагностические и лечебные подходы в клинической практике. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2023;33(2):7–18. https://doi.org/10.22416/1382-4376-2023-33-2-7-18.
  324. Mato JM, Cámara J, Fernández de Paz J, Caballería L, Coll S, Caballero A et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol. 1999;30(6):1081–1089. https://doi.org/10.1016/s0168-8278(99)80263-3.
  325. Rambaldi A, Gluud C. S-adenosyl-L-methionine for alcoholic liver diseases. Cochrane Database Syst Rev. 2006;(2):CD002235. https://doi.org/10.1002/14651858.CD002235.pub2.
  326. Lassailly G, Caiazzo R, Buob D, Pigeyre M, Verkindt H, Labreuche J et al. Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients. Gastroenterology. 2015;149(2):379–388. https://doi.org/10.1053/j.gastro.2015.04.014.
  327. Bower G, Toma T, Harling L, Jiao LR, Efthimiou E, Darzi A et al. Bariatric Surgery and Non-Alcoholic Fatty Liver Disease: a Systematic Review of Liver Biochemistry and Histology. Obes Surg. 2015;25(12):2280–2289. https://doi.org/10.1007/s11695-015-1691-x.
  328. Lee Y, Doumouras AG, Yu J, Brar K, Banfield L, Gmora S et al. Complete Resolution of Nonalcoholic Fatty Liver Disease After Bariatric Surgery: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2019;17(6):1040–1060.e11. https://doi.org/10.1016/j.cgh.2018.10.017.
  329. Fakhry TK, Mhaskar R, Schwitalla T, Muradova E, Gonzalvo JP, Murr MM. Bariatric surgery improves nonalcoholic fatty liver disease: a contemporary systematic review and meta-analysis. Surg Obes Relat Dis. 2019;15(3):502–511. https://doi.org/10.1016/j.soard.2018.12.002.
  330. Zhou H, Luo P, Li P, Wang G, Yi X, Fu Z et al. Bariatric Surgery Improves Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis. Obes Surg. 2022;32(6):1872–1883. https://doi.org/10.1007/s11695-022-06011-1.
  331. Lazarus JV, Mark HE, Anstee QM, Arab JP, Batterham RL, Castera L et al. Advancing the global public health agenda for NAFLD: a consensus statement. Nat Rev Gastroenterol Hepatol. 2022;19(1):60–78. https://doi.org/10.1038/s41575-021-00523-4.
  332. European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease. Obes Facts. 2016;9(2):65–90. https://doi.org/10.1159/000443344.
  333. Fernández T, Viñuela M, Vidal C, Barrera F. Lifestyle changes in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis. PLoS ONE. 2022;17(2):e0263931. https://doi.org/10.1371/journal.pone.0263931.
  334. Glass LM, Hunt CM, Fuchs M, Su GL. Comorbidities and Nonalcoholic Fatty Liver Disease: The Chicken, the Egg, or Both? Fed Pract. 2019;36(2):64–71. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411365/.
  335. Singh S, Singh PP, Singh AG, Murad MH, Sanchez W. Anti-diabetic medications and the risk of hepatocellular cancer: a systematic review and meta-analysis. Am J Gastroenterol. 2013;108(6):881–891. https://doi.org/10.1038/ajg.2013.5.
  336. Ma S, Zheng Y, Xiao Y, Zhou P, Tan H. Meta-analysis of studies using metformin as a reducer for liver cancer risk in diabetic patients. Medicine (Baltimore). 2017;96(19):e6888. https://doi.org/10.1097/MD.0000000000006888.
  337. Zhou YY, Zhu GQ, Liu T, Zheng JN, Cheng Z, Zou TT et al. Systematic Review with Network Meta-Analysis: Antidiabetic Medication and Risk of Hepatocellular Carcinoma. Sci Rep. 2016;6:33743. https://doi.org/10.1038/srep33743.
  338. Singh S, Singh PP, Singh AG, Murad MH, Sanchez W. Statins are associated with a reduced risk of hepatocellular cancer: a systematic review and meta-analysis. Gastroenterology. 2013;144(2):323–332. https://doi.org/10.1053/j.gastro.2012.10.005.
  339. Singal A, Volk ML, Waljee A, Salgia R, Higgins P, Rogers MA, Marrero JA. Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis. Aliment Pharmacol Ther. 2009;30(1):37–47. https://doi.org/10.1111/j.1365-2036.2009.04014.x.
  340. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182–236. https://doi.org/10.1016/j.jhep.2018.03.019.
  341. Machado MV. The Growing Landscape of NAFLD-Associated Hepatocellular Carcinoma and Its Impact in Surveillance. GE Port J Gastroenterol. 2023;31(1):14–23. https://doi.org/10.1159/000531397.
  342. Younossi Z, Stepanova M, Ong JP, Jacobson IM, Bugianesi E, Duseja A et al. Nonalcoholic Steatohepatitis Is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates. Clin Gastroenterol Hepatol. 2019;17(4):748–755.e3. https://doi.org/10.1016/j.cgh.2018.05.057.
  343. Ducreux M, Abou-Alfa GK, Bekaii-Saab T, Berlin J, Cervantes A, de Baere T et al. The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022. ESMO Open. 2023;8(3):101567. https://doi.org/10.1016/j.esmoop.2023.101567.
  344. Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, Angulo P. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129(1):113–121. https://doi.org/10.1053/j.gastro.2005.04.014.
  345. Hashimoto E, Yatsuji S, Tobari M, Taniai M, Torii N, Tokushige K, Shiratori K. Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. J Gastroenterol. 2009;44(Suppl. 19):89–95. https://doi.org/10.1007/s00535-008-2262-x.
  346. Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF, Zein NN. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology. 2010;51(6):1972–1978. https://doi.org/10.1002/hep.23527.
  347. Bertot LC, Jeffrey GP, Wallace M, MacQuillan G, Garas G, Ching HL, Adams LA. Nonalcoholic fatty liver disease-related cirrhosis is commonly unrecognized and associated with hepatocellular carcinoma. Hepatol Commun. 2017;1(1):53–60. https://doi.org/10.1002/hep4.1018.
  348. Than NN, Ghazanfar A, Hodson J, Tehami N, Coldham C, Mergental H et al. Comparing clinical presentations, treatments and outcomes of hepatocellular carcinoma due to hepatitis C and non-alcoholic fatty liver disease. QJM. 2017;110(2):73–81. https://doi.org/10.1093/qjmed/hcw151.
  349. Yoo JJ, Park MY, Cho EJ, Yu SJ, Kim SG, Kim YJ, et al. Smoking Increases the Risk of Hepatocellular Carcinoma and Cardiovascular Disease in Patients with Metabolic-Associated Fatty Liver Disease. J Clin Med. 2023 May 8;12(9):3336. doi: 10.3390/jcm12093336.
  350. Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen CH et al. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 2017;127(7):2697–2704. https://doi.org/10.1172/JCI93465.
  351. Wijarnpreecha K, Thongprayoon C, Ungprasert P. Coffee consumption and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2017;29(2):e8–e12. https://doi.org/10.1097/MEG.0000000000000776.
  352. Hayat U, Siddiqui AA, Okut H, Afroz S, Tasleem S, Haris A. The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: A meta-analysis of 11 epidemiological studies. Ann Hepatol. 2021;20:100254. https://doi.org/10.1016/j.aohep.2020.08.071.
  353. Kennedy OJ, Roderick P, Buchanan R, Fallowfield JA, Hayes PC, Parkes J. Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose-response meta-analysis. BMJ Open. 2017;7(5):e013739. https://doi.org/10.1136/bmjopen-2016-013739.
  354. Shen H, Rodriguez AC, Shiani A, Lipka S, Shahzad G, Kumar A, Mustacchia P. Association between caffeine consumption and nonalcoholic fatty liver disease: a systemic review and meta-analysis. Therap Adv Gastroenterol. 2016;9(1):113–120. https://doi.org/10.1177/1756283X15593700.
  355. Chen YP, Lu FB, Hu YB, Xu LM, Zheng MH, Hu ED. A systematic review and a dose-response meta-analysis of coffee dose and nonalcoholic fatty liver disease. Clin Nutr. 2019;38(6):2552–2557. https://doi.org/10.1016/j.clnu.2018.11.030.
  356. Marventano S, Salomone F, Godos J, Pluchinotta F, Del Rio D, Mistretta A, Grosso G. Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies. Clin Nutr. 2016;35(6):1269–1281. https://doi.org/10.1016/j.clnu.2016.03.012.
  357. Ebadi M, Ip S, Bhanji RA, Montano-Loza AJ. Effect of Coffee Consumption on Non-Alcoholic Fatty Liver Disease Incidence, Prevalence and Risk of Significant Liver Fibrosis: Systematic Review with Meta-Analysis of Observational Studies. Nutrients. 2021;13(9):3042. https://doi.org/10.3390/nu13093042.
  358. Birerdinc A, Stepanova M, Pawloski L, Younossi ZM. Caffeine is protective in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2012;35(1):76–82. https://doi.org/10.1111/j.1365-2036.2011.04916.x.
  359. Inoue M, Yoshimi I, Sobue T, Tsugane S. Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan. J Natl Cancer Inst. 2005;97(4):293–300. https://doi.org/10.1093/jnci/dji040.
  360. Johnson S, Koh WP, Wang R, Govindarajan S, Yu MC, Yuan JM. Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study. Cancer Causes Control. 2011;22(3):503–510. https://doi.org/10.1007/s10552-010-9725-0.
  361. Hu G, Tuomilehto J, Pukkala E, Hakulinen T, Antikainen R, Vartiainen E, Jousilahti P. Joint effects of coffee consumption and serum gamma-glutamyltransferase on the risk of liver cancer. Hepatology. 2008;48(1):129–136. https://doi.org/10.1002/hep.22320.
  362. Tanaka K, Hara M, Sakamoto T, Higaki Y, Mizuta T, Eguchi Y et al. Inverse association between coffee drinking and the risk of hepatocellular carcinoma: a case-control study in Japan. Cancer Sci. 2007;98(2):214–218. https://doi.org/10.1111/j.1349-7006.2006.00368.x.
  363. Zhang XL, Wang TY, Targher G, Byrne CD, Zheng MH. Lifestyle Interventions for Non-Obese Patients Both with, and at Risk, of Non-Alcoholic Fatty Liver Disease. Diabetes Metab J. 2022;46(3):391-401. doi: 10.4093/dmj.2022.0048.
  364. Zhao Y, Zhao W, Wang H, Zhao Y, Bu H, Takahashi H. Pioglitazone on nonalcoholic steatohepatitis: A systematic review and meta-analysis of 15 RCTs. Medicine (Baltimore). 2022;101(46):e31508. doi: 10.1097/MD.0000000000031508.
  365. Machado FHF, Castro Filho HF, Babadopulos RFAL, Rocha HAL, Rocha JLC, Moraes Filho MO. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass1. Acta Cir Bras. 2019 Feb 14;34(1):e20190010000009. doi: 10.1590/s0102-865020190010000009. Erratum in: Acta Cir Bras. 2019;34(4):e2019004ERRATA. doi: 10.1590/s0102-865020190010000009erratum.
  366. Ratziu V, Massard J, Charlotte F, Messous D, Imbert-Bismut F, Bonyhay L, Tahiri M, Munteanu M, Thabut D, Cadranel JF, Le Bail B, de Ledinghen V, Poynard T; LIDO Study Group; CYTOL study group. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol. 2006;6:6. doi: 10.1186/1471-230X-6-6.
  367. Vali Y, Lee J, Boursier J, Spijker R, Verheij J, Brosnan MJ, Anstee QM, Bossuyt PM, Zafarmand MH, On Behalf Of The Litmus Systematic Review Team. FibroTest for Evaluating Fibrosis in Non-Alcoholic Fatty Liver Disease Patients: A Systematic Review and Meta-Analysis. J Clin Med. 2021;10(11):2415. doi: 10.3390/jcm10112415.

Для продолжения работы требуется Регистрация
На предыдущую страницу

Предыдущая страница

Следующая страница

На следующую страницу
Список литературы
На предыдущую главу Предыдущая глава
оглавление
Следующая глава На следующую главу

Оглавление

Данный блок поддерживает скрол*