1. TOPICS TO DISCUSS
1. Classification of drugs inhibiting adrenergic synapses.
2. Localizations of action of drugs inhibiting ad-renergic synapses on the diagram of adrenergic varicosity.
3. Pharmacological effects of nonselective a-adrenoblocking drugs (action on vascular tone, arterial blood pressure, heart rate). Epi-nephrine reversal. Therapeutic uses and adverse effects. The difference between phentolamine and phenoxybenzamine.
4. Pharmacological effects of a1-adrenoblocking drugs (action on vascular tone, arterial blood pressure, heart rate, tone of bladder neck, prostate capsule, and urethra). Therapeutic uses and adverse effects. The difference between prazo-sin, terazosin, and tamsulosin.
5. Pharmacological effects of β1 β2-adrenoblockers: propranolol, nadolol, timolol. The main therapeutic use of β1,β2-adrenoblockers. Mechanisms of antihypertensive, antianginal and antiar-rhythmic effects. Other therapeutic uses of pro-pranolol.
6. Therapeutic use of timolol. Mechanism of action on intraocular pressure.
7. The main adverse effects of nonselective β-adrenoblockers resulting from blockade of β1-adrenoceptors and β2-adrenoceptors. Other adverse effects of p-adrenoblocking drugs. Withdrawal syndrome.
8. Selective β1-adrenoblockers: metoprolol, at-enolol, betaxolol, esmolol, bisoprolol, nebivo-lol. Main therapeutic uses, adverse effects. Comparison with nonselective adrenoblocking drugs.
9. β-Adrenoblockers with intrinsic sympathomi-metic activity: acebutolol, oxprenolol, pindolol. Comparison with pure antagonists of p-adreno-ceptors. Therapeutic uses, adverse effects.
10. Nonselective a, β-adrenoblocking drugs: labetalol, carvedilol. Therapeutic uses, adverse effects.
11. Pharmacological effects and mechanisms of action of adrenergic neuron-blocking drugs (reserpine, guanethidine). Main therapeutic uses and adverse effects.