1. TOPICS TO DISCUSS
1. Glucocorticoids and their synthetic analogues. Basic mechanism of glucocorticoid action at molecular level.
2. Mechanisms of anti-inflammatory, immuno-suppressive and antiallergic actions.
3. Main metabolic effects of glucocorticoids and their mechanisms. Negative feedback effect on the pituitary and hypothalamus.
4. Main therapeutic use of glucocorticoids.
5. Main adverse effects of glucocorticoids and their mechanisms.
6. Mineralocorticoids. Pharmacological effects and mechanism of mineralocorticoid action. The main therapeutic uses.
7. Estrogens and their synthetic analogues. Main pharmacological effects, basic mechanism of action and clinical uses. Adverse effects.
8. Selective estrogen receptor modulators (SERM). Main pharmacological effects, mechanisms of action and clinical uses. Comparison with estrogens.
9. Progestins. Main pharmacological effects, mechanism of action and clinical uses. Adverse effects. Antiprogestins.
10. Combination pills for contraception and postmenopausal therapy. Progestin-only contraception. Mechanisms of action. Adverse effects of contraceptives.
11. Androgens and their synthetic analogues. Pharmacological effects. Main therapeutic uses. Adverse effects
12. Antiandrogens. Main therapeutic uses. Adverse effects.
13. Anabolic steroids. Pharmacological effects. Main therapeutic uses.
14. Inhibitors of steroid hormone synthesis: ami-noglutethimide, metyrapone, finasteride, letrozole. Mechanisms of action, pharmacological effects. Main therapeutic uses.
2. CLASSIFICATION OF STEROID HORMONE PREPARATIONS AND
RELATED DRUGS
Glucocorticoids
Hydrocortisone, Prednisolone, Methylprednisolone, Dexamethasone, Betamethasone, Beclomethasone, Fluticasone, Flunisolide, Budesonide, Ciclesonide, Clobetasole, Mometasone, Triamcinolone Mineralocorticoids and their antagonists Aldosterone, Fludrocortisone, Spironolactone, Eplerenone