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Chapter 14. MENOPAUSE AND MENOPAUSAL HORMONE THERAPY

Climax (climacteric) is a physiological condition in a woman's life, which is characterized by a transition from reproductive to an older age.

However, 80% of women in the period of menopause have a climacteric (menopausal) syndrome, which is manifested by various neuropsychiatric, vegetative-vascular and other disorders caused by estrogen deficiency.

The path from menarche to menopause is generally regarded as a process of predictable and gradual aging of the female reproductive system.

Currently, more than a third of a woman's life falls into the period of menopause. Many chronic diseases develop and manifest, starting from the sixth decade, which can affect both the quality and span of a woman's life. Obesity, metabolic syndrome and diabetes, cardiovascular diseases, osteoporosis and osteoarthritis, cognitive decline, intellectual deterioration, depression, and cancer are the main diseases that accompany advanced age.

Menopause onset predicts the possibility of improvement of life quality and increasing its duration regarding the prevention strategy for many diseases that accompany advanced age. Prophylaxis of the above mentioned diseases includes lifestyle modification: smoking cessation and abstaining from excessive alcohol consumption, a healthy and balanced diet, regular physical activity, and mentally stimulating activities.

Menopausal hormone therapy (MHT) occupies a special place in the strategy of prevention of diseases accompanying postmenopausal women.

Menopausal hormone therapy is the use of hormonal drugs aimed at suppressing menopausal symptoms associated with estrogen deficiency. Variants of menopausal hormone therapy:

► oral (tablets);

► transdermal (skin patches, gels, etc.). Types of menopausal hormone therapy:

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