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8. TYPICAL DERANGEMENTS OF LIPID METABOLISM. ATHEROSCLEROSIS

I. Insufficiency of lipid uptake in the small intestine can result from the following:

1. Cholelithiasis.

2. Insufficiency of lipase secretion with pancreatic juice.

3. Insufficiency of vitamin E in the body.

4. Injury of the small intestine epithelium.

5. Impairment of glycerol phosphorylation in enterocytes.

6. Insufficient production of triglycerol lipase by adipocytes.

II. Choose the correct answers.

1. Lipoproteins are complexes of proteins and lipids linked together by noncovalent bonds.

2. Lipoproteins of different classes have constant composition.

3. Lipoproteins are formed by many cells of the peripheral tissues including adipocytes.

4. Lipoproteins consist of a hydrophobic nucleus and a hydrophilic shell.

III. The following is typical for high-density lipoproteins:

1. High relative content of proteins.

2. High relative content of triglycerol.

3. Apoprotein B is a basic protein component of lipoproteins.

4. They possess antiatherogenic activity.

5. Apoprotein A is a basic protein component of lipoproteins.

6. They are mainly produced by the liver.

7. They are formed in the circulating blood.

IV. Hyperlipidemia can be induced by the following mechanisms:

1. Abnormalities of receptors that bind low-density lipoproteins.

2. Low activity of adipocyte triglycerol lipase.

3. Mutation of gene for apoprotein E.

4. A decrease in lipoprotein lipase activity in plasma.

5. Mutation of gene for apoprotein B.

6. Increased secretion of glucagons.

7. Mutation of gene for apoprotein A.

V. Hypolipidemia can be induced by the following mechanisms:

1. Mutation of gene for apoprotein A.

2. A decrease in lipoprotein lipase activity in plasma.

3. Null mutation of gene for apoprotein B.

4. Severe liver insufficiency.

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