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PATHOPHYSIOLOGY OF THE BLOOD SYSTEM

Normal results of the complete blood test with differential

Hemoglobin (Hb) - 130-160 g/L (men); 120-150 g/L (women). Erythrocytes - 4.2-5.9x1012/L (men); 3.9-4.6x1012/L (women).

Mean corpuscular Hb (MCH) - 25-33 pg.

Reticulocytes - 0.5-2.5%. Platelets - 150-350x1012/L. Leukocytes - 4.5-10.5x109/L. Neutrophils:

myelocytes - 0;

metamyelocytes - 0;

band - 1-6%;

segmented - 47-72%.

Eosinophils - 2.0-4.0%. Basophils - 0.5-1%. Lymphocytes/plasmocytes - 20-25%/0. Monocytes - 3-8%.

Erythrocytes sedimentation rate (ESR) - 1-13 mm/h (men); 1-20 mm/h (women).

Hematokrit (Ht) - 0.45-0.52 (men); 0.37-0.48 (women)

Characterize changes in the complete blood tests with differential, and indicate their possible causes, mechanisms of development and consequences. Make a general conclusion on the results of tests.

Symbol «?» indicates that the referred parameter should be calculated.

N 170

N 171

Hb

150 g/L

112 g/L

Erythrocytes

4.7x1012/L

4.1x1012/L

MCH

?

?

Reticulocytes

0.5%

0.2%

Platelets

220x109/L

130x109/L

Leukocytes

17.0x109/L

21.5x109/L

Neutrophils:

myelocytes

0

0

metamyelocytes

4%

0

band

16%

0

segmented

60%

3%

Eosinophils

1%

0

Basophils

0

0

Lymphocytes

15%

89%

Monocytes

4%

8%

Few lymphoblasts are present

N 172

N 173

Hb

54 g/L

89 g/L

Erythrocytes

1.0x1012/L

3.0x1012/L

MCH

?

?

Reticulocytes

0

0

Platelets

few

85x109/L

Leukocytes

11.3x109/L

0.9x109/L

Neutrophils:

23%

myelocytes

0

metamyelocytes

0

band

2%

segmented

10%

Eosinophils

0

10%

Basophils

0

0

Lymphocytes

78%

55%

Lymphoblasts

7%

Monocytes

3%

12%

ESR

68 mm/h

*

**

* Anisocytosis and microcytosis of erythrocytes.

** High blood levels of IgG, IgM, and factors of complement; an increased blood concentration of unconjugated bilirubin.

N 174

N 175

Hb

48 g/L

162 g/L

Erythrocytes

0.8x1012/L

4.7x1012/L

MCH

?

?

Reticulocytes

0.3%

1.0%

Platelets

180x109/L

250x109/L

Leukocytes

88.0x109/L

39.0x109/L

Promyelocytes

0

0

Neutrophils:

myelocytes

0

6%

metamyelocytes

0

10.5%

N 174

N 175

band

1%

19%

segmented

2%

25.5%

Eosinophils

1%

0

Basophils

0

0

Lymphocytes

60%

27%

Lymphoblasts

35%

0

Monocytes

1%

12%

N 176

N 177

Hb

100 g/L

95 g/L

Erythrocytes

3.6x1012/L

3.7x1012/L

MCH

?

?

Reticulocytes

0.6%

3%

Platelets

200x109/L

110x109/L

Leukocytes

36.0x109/L

2.9x109/L

Myeloblasts

0

33%

Promyelocytes

0

1%

Neutrophils:

myelocytes

0

0

metamyelocytes

6%

0

band

9%

2%

segmented

11%

10%

Eosinophils

60%

20%

Basophils

0

0

Lymphocytes

12%

32%

Monocytes

2%

2%

N 178

N 179

Hb

190 g/L

170 g/L

Erythrocytes

7.4x1012/L

5.3x1012/L

MCH

?

?

Reticulocytes

1.6%

0.5%

Platelets

550x109/L

480x109/L

Leukocytes

11.0x109/L

16.5x109/L

Myeloblasts

0

33%

Promyelocytes

0

1%

Neutrophils:

myelocytes

0

0

metamyelocytes

0.5%

3%

band

16%

16%

segmented

56%

70%

Eosinophils

11%

1%

Basophils

1.5%

0

Lymphocytes

12%

3%

Monocytes

3%

7%

ESR

10 mm/h

1 mm/h

*

**

* Significant polychromatophylia of erythrocytes, few normoblasts.

** Anisocytosis and macrocytosis of erythrocytes.

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